Insights from a Thermodynamic Study and Its Implications on the Freeze-Drying of Pharmaceutical Solutions Containing Water and tert-Butyl Alcohol as a Cosolvent

¹Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, 100 Bertelsmeyer Hall, 1101 North State Street, Rolla, Missouri 65409-1230; and
²Criofarma-Freeze Drying Equipment, Strada del Francese 97/2L, 10156 Turin, Italy

↵* Corresponding Author: Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, 100 Bertelsmeyer Hall, 1101 North State Street, Rolla, Missouri 65409-1230. Telephone: +1-573-341-6705; Fax: +1-573-341-4377; e-mail: ail{at}mst.edu