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Research ArticleResearch

Retrospective Evaluation of Cycled Resin in Viral Clearance Studies—A Multiple Company Collaboration

John Mattila, Sherrie Curtis, Yenny Webb-Vargas, Eileen Wilson, Olga Galperina, David Roush, Scott Tobler, Bradford Stanley, Mike Clark, Justin Weaver, Jeremy Pike, Deqiang Yu, Xinfang Li, Andreas Flicker, Johanna Kindermann, Norbert Schuelke, Richard Whitcombe and Louise Bennett
PDA Journal of Pharmaceutical Science and Technology September 2019, 73 (5) 470-486; DOI: https://doi.org/10.5731/pdajpst.2018.009605
John Mattila
1Regeneron Pharmaceuticals Inc., Tarrytown, NY;
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Sherrie Curtis
2Genentech, Inc., South San Francisco, CA;
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Yenny Webb-Vargas
2Genentech, Inc., South San Francisco, CA;
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Eileen Wilson
3GlaxoSmithKline plc, King of Prussia, PA;
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Olga Galperina
4GlaxoSmithKline plc, Rockville, MD;
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David Roush
5Merck & Co., Inc., Kenilworth, NJ, USA;
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Scott Tobler
5Merck & Co., Inc., Kenilworth, NJ, USA;
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Bradford Stanley
6Biogen, Research Triangle Park, NC;
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Mike Clark
7AbbVie Bioresearch Center, Worcester, MA;
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Justin Weaver
8Alexion Pharmaceuticals, Inc. Boston, MA;
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Jeremy Pike
8Alexion Pharmaceuticals, Inc. Boston, MA;
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Deqiang Yu
9Bristol-Myers Squibb, Devens MA;
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Xinfang Li
10ImmunoGen, Inc. Waltham, MA;
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Andreas Flicker
11Shire plc, Lexington, MA;
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Johanna Kindermann
11Shire plc, Lexington, MA;
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Norbert Schuelke
12Takeda Pharmaceuticals International Co., Cambridge, MA;
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Richard Whitcombe
13UCB, Brussels, Belgium; and
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Louise Bennett
14BioPhorum Operations Group, London, U.K.
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  • For correspondence: bennettl@biophorum.com
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Article Information

vol. 73 no. 5 470-486
DOI 
https://doi.org/10.5731/pdajpst.2018.009605
PubMed 
31101706

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online October 9, 2019.

Article Versions

  • previous version (May 17, 2019 - 05:08).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© PDA, Inc. 2019

Author Information

  1. John Mattila1,
  2. Sherrie Curtis2,
  3. Yenny Webb-Vargas2,
  4. Eileen Wilson3,
  5. Olga Galperina4,
  6. David Roush5,
  7. Scott Tobler5,
  8. Bradford Stanley6,
  9. Mike Clark7,
  10. Justin Weaver8,
  11. Jeremy Pike8,
  12. Deqiang Yu9,
  13. Xinfang Li10,#,
  14. Andreas Flicker11,
  15. Johanna Kindermann11,
  16. Norbert Schuelke12,
  17. Richard Whitcombe13 and
  18. Louise Bennett14,*
  1. 1Regeneron Pharmaceuticals Inc., Tarrytown, NY;
  2. 2Genentech, Inc., South San Francisco, CA;
  3. 3GlaxoSmithKline plc, King of Prussia, PA;
  4. 4GlaxoSmithKline plc, Rockville, MD;
  5. 5Merck & Co., Inc., Kenilworth, NJ, USA;
  6. 6Biogen, Research Triangle Park, NC;
  7. 7AbbVie Bioresearch Center, Worcester, MA;
  8. 8Alexion Pharmaceuticals, Inc. Boston, MA;
  9. 9Bristol-Myers Squibb, Devens MA;
  10. 10ImmunoGen, Inc. Waltham, MA;
  11. 11Shire plc, Lexington, MA;
  12. 12Takeda Pharmaceuticals International Co., Cambridge, MA;
  13. 13UCB, Brussels, Belgium; and
  14. 14BioPhorum Operations Group, London, U.K.
  1. ↵* Corresponding Author: BioPhorum Operations Group, London, U.K.; e-mail: bennettl{at}biophorum.com
  • ↵#  Present address: MabPlex International Co., Ltd, Yantai, Shandong, China

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PDA Journal of Pharmaceutical Science and Technology: 73 (5)
PDA Journal of Pharmaceutical Science and Technology
Vol. 73, Issue 5
September/October 2019
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Retrospective Evaluation of Cycled Resin in Viral Clearance Studies—A Multiple Company Collaboration
John Mattila, Sherrie Curtis, Yenny Webb-Vargas, Eileen Wilson, Olga Galperina, David Roush, Scott Tobler, Bradford Stanley, Mike Clark, Justin Weaver, Jeremy Pike, Deqiang Yu, Xinfang Li, Andreas Flicker, Johanna Kindermann, Norbert Schuelke, Richard Whitcombe, Louise Bennett
PDA Journal of Pharmaceutical Science and Technology Sep 2019, 73 (5) 470-486; DOI: 10.5731/pdajpst.2018.009605

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Retrospective Evaluation of Cycled Resin in Viral Clearance Studies—A Multiple Company Collaboration
John Mattila, Sherrie Curtis, Yenny Webb-Vargas, Eileen Wilson, Olga Galperina, David Roush, Scott Tobler, Bradford Stanley, Mike Clark, Justin Weaver, Jeremy Pike, Deqiang Yu, Xinfang Li, Andreas Flicker, Johanna Kindermann, Norbert Schuelke, Richard Whitcombe, Louise Bennett
PDA Journal of Pharmaceutical Science and Technology Sep 2019, 73 (5) 470-486; DOI: 10.5731/pdajpst.2018.009605
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Keywords

  • Viral clearance
  • packed bed chromatography
  • Resin reuse
  • Protein A
  • anion exchange

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