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Research ArticleResearch

A Validation Study of the Limulus Amebocyte Lysate Test as an End-Product Endotoxin Test for Polyvalent Horse Snake Antivenom

Norhan S. Sheraba, Mohamed R. Diab, Aymen S. Yassin, Magdy A. Amin and Hamdallah H. Zedan
PDA Journal of Pharmaceutical Science and Technology November 2019, 73 (6) 562-571; DOI: https://doi.org/10.5731/pdajpst.2018.009522
Norhan S. Sheraba
1Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia;
2VACSERA, The Holding Company for Biological Products and Vaccines, Giza, Egypt; and
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  • For correspondence: nsherbah@kku.edu.sa
Mohamed R. Diab
2VACSERA, The Holding Company for Biological Products and Vaccines, Giza, Egypt; and
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Aymen S. Yassin
3Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt
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Magdy A. Amin
3Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt
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Hamdallah H. Zedan
3Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt
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Article Information

vol. 73 no. 6 562-571
DOI 
https://doi.org/10.5731/pdajpst.2018.009522
PubMed 
30770487

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online December 10, 2019.

Article Versions

  • previous version (October 15, 2019 - 08:43).
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Copyright & Usage 
© PDA, Inc. 2019

Author Information

  1. Norhan S. Sheraba1,2,*,
  2. Mohamed R. Diab2,
  3. Aymen S. Yassin3,
  4. Magdy A. Amin3 and
  5. Hamdallah H. Zedan3
  1. 1Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia;
  2. 2VACSERA, The Holding Company for Biological Products and Vaccines, Giza, Egypt; and
  3. 3Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt
  1. ↵* Corresponding Author: Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, P.O. Box: 960, Postal Code: 61421, Kingdom of Saudi Arabia. Telephone: 011+ 966+ 172418000; Mobile number: +966 583637720; e-mail: nsherbah{at}kku.edu.sa.
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PDA Journal of Pharmaceutical Science and Technology: 73 (6)
PDA Journal of Pharmaceutical Science and Technology
Vol. 73, Issue 6
November/December 2019
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A Validation Study of the Limulus Amebocyte Lysate Test as an End-Product Endotoxin Test for Polyvalent Horse Snake Antivenom
Norhan S. Sheraba, Mohamed R. Diab, Aymen S. Yassin, Magdy A. Amin, Hamdallah H. Zedan
PDA Journal of Pharmaceutical Science and Technology Nov 2019, 73 (6) 562-571; DOI: 10.5731/pdajpst.2018.009522

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A Validation Study of the Limulus Amebocyte Lysate Test as an End-Product Endotoxin Test for Polyvalent Horse Snake Antivenom
Norhan S. Sheraba, Mohamed R. Diab, Aymen S. Yassin, Magdy A. Amin, Hamdallah H. Zedan
PDA Journal of Pharmaceutical Science and Technology Nov 2019, 73 (6) 562-571; DOI: 10.5731/pdajpst.2018.009522
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Keywords

  • Polyvalent horse snake antivenom
  • Endotoxin
  • LAL
  • Validation study
  • Maximum valid dilution
  • Interference factors

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