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Research ArticleResearch

Drug Formulation Impact on Prefilled Syringe Functionality and Autoinjector Performance

Liang Fang, Galen Huaiqiu Shi, Coralie ADÈle Richard, Xia Dong, Justin C. Thomas, Michael C. Victor, Tingting Wang, Sharon Shinkle and Cathy Zhao
PDA Journal of Pharmaceutical Science and Technology November 2020, 74 (6) 674-687; DOI: https://doi.org/10.5731/pdajpst.2020.011627
Liang Fang
1West Pharmaceutical Services, Inc.; 530 Herman O. West Drive, Exton, PA 19341; and
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Galen Huaiqiu Shi
2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46265
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  • For correspondence: galen_shi@lilly.com
Coralie ADÈle Richard
2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46265
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Xia Dong
2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46265
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Justin C. Thomas
2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46265
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Michael C. Victor
2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46265
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Tingting Wang
2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46265
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Sharon Shinkle
2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46265
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Cathy Zhao
1West Pharmaceutical Services, Inc.; 530 Herman O. West Drive, Exton, PA 19341; and
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Article Information

vol. 74 no. 6 674-687
DOI 
https://doi.org/10.5731/pdajpst.2020.011627
PubMed 
32817321

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online December 10, 2020.

Article Versions

  • previous version (August 14, 2020 - 07:58).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© PDA, Inc. 2020

Author Information

  1. Liang Fang1,
  2. Galen Huaiqiu Shi2,*,
  3. Coralie ADÈle Richard2,
  4. Xia Dong2,
  5. Justin C. Thomas2,
  6. Michael C. Victor2,
  7. Tingting Wang2,
  8. Sharon Shinkle2 and
  9. Cathy Zhao1
  1. 1West Pharmaceutical Services, Inc.; 530 Herman O. West Drive, Exton, PA 19341; and
  2. 2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46265
  1. ↵* Corresponding Author: Lilly Corporate Center, Indianapolis, IN 46265; Telephone: 317-655-0178; E-mail: galen_shi{at}lilly.com
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PDA Journal of Pharmaceutical Science and Technology: 74 (6)
PDA Journal of Pharmaceutical Science and Technology
Vol. 74, Issue 6
November/December 2020
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Drug Formulation Impact on Prefilled Syringe Functionality and Autoinjector Performance
Liang Fang, Galen Huaiqiu Shi, Coralie ADÈle Richard, Xia Dong, Justin C. Thomas, Michael C. Victor, Tingting Wang, Sharon Shinkle, Cathy Zhao
PDA Journal of Pharmaceutical Science and Technology Nov 2020, 74 (6) 674-687; DOI: 10.5731/pdajpst.2020.011627

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Drug Formulation Impact on Prefilled Syringe Functionality and Autoinjector Performance
Liang Fang, Galen Huaiqiu Shi, Coralie ADÈle Richard, Xia Dong, Justin C. Thomas, Michael C. Victor, Tingting Wang, Sharon Shinkle, Cathy Zhao
PDA Journal of Pharmaceutical Science and Technology Nov 2020, 74 (6) 674-687; DOI: 10.5731/pdajpst.2020.011627
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Keywords

  • prefilled syringe
  • Autoinjector
  • Glide force
  • Injection time
  • Hansen solubility parameters
  • Interfacial tension
  • Contact angle
  • Silicone oil
  • Drug formulation

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