Container Closure Integrity Test Using Frequency Modulation Spectroscopy Headspace Analysis with Carbon Dioxide as a Tracer Gas

Allison Alix Caudill; Ken Victor; Michael Timmins; James Veale

doi:10.5731/pdajpst.2020.011502

Research ArticleTechnology/Application

Container Closure Integrity Test Using Frequency Modulation Spectroscopy Headspace Analysis with Carbon Dioxide as a Tracer Gas

Allison Alix Caudill, Ken Victor, Michael Timmins and James Veale

PDA Journal of Pharmaceutical Science and Technology March 2021, 75 (2) 157-172; DOI: https://doi.org/10.5731/pdajpst.2020.011502

Allison Alix Caudill

Lighthouse Instruments, LLC., Charlottesville, VA 22902, USA

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For correspondence: acaudill@lighthouseinstruments.com

Ken Victor

Lighthouse Instruments, LLC., Charlottesville, VA 22902, USA

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Michael Timmins

Lighthouse Instruments, LLC., Charlottesville, VA 22902, USA

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James Veale

Lighthouse Instruments, LLC., Charlottesville, VA 22902, USA

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vol. 75 no. 2 157-172

DOI

https://doi.org/10.5731/pdajpst.2020.011502

PubMed

33067331

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online April 1, 2021.

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previous version (October 16, 2020 - 09:14).
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Allison Alix Caudill*,
Ken Victor,
Michael Timmins and
James Veale

Lighthouse Instruments, LLC., Charlottesville, VA 22902, USA

↵*Corresponding Author: Lighthouse Instruments, LLC., 2020 Avon Ct., Suite #2, Charlottesville, VA 22902; Telephone +1 434 293 3081, ext 267; E-mail: acaudill{at}lighthouseinstruments.com

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Container Closure Integrity Test Using Frequency Modulation Spectroscopy Headspace Analysis with Carbon Dioxide as a Tracer Gas

Allison Alix Caudill, Ken Victor, Michael Timmins, James Veale

PDA Journal of Pharmaceutical Science and Technology Mar 2021, 75 (2) 157-172; DOI: 10.5731/pdajpst.2020.011502

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Container Closure Integrity Test Using Frequency Modulation Spectroscopy Headspace Analysis with Carbon Dioxide as a Tracer Gas

Allison Alix Caudill, Ken Victor, Michael Timmins, James Veale

PDA Journal of Pharmaceutical Science and Technology Mar 2021, 75 (2) 157-172; DOI: 10.5731/pdajpst.2020.011502

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Keywords

Container closure integrity
USP <1207>
Headspace gas analysis
Frequency modulation spectroscopy
Laser-drilled defects
Microwires
Blue dye ingress test
Microbial ingress test

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