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Research ArticleTechnology/Application

Statistical Method for Trending of Excursions in Clean Room Microbiological Monitoring Data

K. Rao Gurijala and Andrew Barnett
PDA Journal of Pharmaceutical Science and Technology September 2021, 75 (5) 407-424; DOI: https://doi.org/10.5731/pdajpst.2020.011791
K. Rao Gurijala
NSF Health Sciences, Washington, DC
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  • For correspondence: rao.gurijala@asepsisinternational.com
Andrew Barnett
NSF Health Sciences, Washington, DC
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  • Article
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Article Information

vol. 75 no. 5 407-424
DOI 
https://doi.org/10.5731/pdajpst.2020.011791
PubMed 
33608470

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online September 27, 2021.

Article Versions

  • previous version (February 19, 2021 - 05:13).
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Copyright & Usage 
© PDA, Inc. 2021

Author Information

  1. K. Rao Gurijala* and
  2. Andrew Barnett
  1. NSF Health Sciences, Washington, DC
  1. ↵*Corresponding Author. Present Address: Asepsis Consulting International LLC, 7 Crest Wood Circle, Pittsford, NY 14534; Telephone: (585) 281-1482; E-mail: rao.gurijala{at}asepsisinternational.com
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PDA Journal of Pharmaceutical Science and Technology: 75 (5)
PDA Journal of Pharmaceutical Science and Technology
Vol. 75, Issue 5
September/October 2021
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Statistical Method for Trending of Excursions in Clean Room Microbiological Monitoring Data
K. Rao Gurijala, Andrew Barnett
PDA Journal of Pharmaceutical Science and Technology Sep 2021, 75 (5) 407-424; DOI: 10.5731/pdajpst.2020.011791

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Statistical Method for Trending of Excursions in Clean Room Microbiological Monitoring Data
K. Rao Gurijala, Andrew Barnett
PDA Journal of Pharmaceutical Science and Technology Sep 2021, 75 (5) 407-424; DOI: 10.5731/pdajpst.2020.011791
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  • Article
    • Abstract
    • Introduction
    • Determination of Action and Alert Levels Based on Historical Data
    • Rationale for Using Percentile Method to Determine Action and Alert Levels
    • Definition of Adverse Trends
    • Determination of Adverse Trends in Quarterly and Annual Trend Analyses
    • Determination of Adverse Trends at the Onset of an Excursion Result
    • Type I and Type II Errors
    • Trend Rules Based on Binomial Probability
    • Ongoing Processes
    • Mature Processes
    • Intermediate Processes
    • New Processes
    • Handling of Adverse Trends
    • Case Study
    • Recommendations for Implementation
    • Sample Trend Charts
    • Discussion
    • Conclusion
    • Conflict of Interest Declaration
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

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Keywords

  • Adverse trends
  • Alert levels
  • Action levels
  • Alert level excursion rates
  • Microbial recovery rates
  • Operational characteristics curves
  • Environmental monitoring
  • Bioburden tests
  • Nonparametric methods
  • Average run length
  • false positives
  • false negatives

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