100% Control of Controlled Ice Nucleation Vials by Camera-Supported Optical Inspection in Freeze-Drying

Julian H. Lenger; Raimund Geidobler; Werner Halbinger; Ingo Presser; Gerhard Winter

doi:10.5731/pdajpst.2020.012575

Research ArticleTechnology/Application

100% Control of Controlled Ice Nucleation Vials by Camera-Supported Optical Inspection in Freeze-Drying

Julian H. Lenger, Raimund Geidobler, Werner Halbinger, Ingo Presser and Gerhard Winter

PDA Journal of Pharmaceutical Science and Technology March 2022, 76 (2) 120-135; DOI: https://doi.org/10.5731/pdajpst.2020.012575

Julian H. Lenger

1Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München

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For correspondence: julian.lenger@bayer.com gerhard.winter@cup.uni-muenchen.de

Raimund Geidobler

2Pharmaceutical Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG; and

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Werner Halbinger

3Seidenader Maschinenbau GmbH (Körber AG)

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Ingo Presser

2Pharmaceutical Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG; and

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Gerhard Winter

1Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München

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For correspondence: julian.lenger@bayer.com gerhard.winter@cup.uni-muenchen.de

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vol. 76 no. 2 120-135

DOI

https://doi.org/10.5731/pdajpst.2020.012575

PubMed

34131013

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Parenteral Drug Association (PDA)

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1079-7440

Online ISSN

1948-2124

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Published online April 1, 2022.

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previous version (June 15, 2021 - 08:06).
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Julian H. Lenger^1,*,^,#,
Raimund Geidobler²,
Werner Halbinger³,
Ingo Presser² and
Gerhard Winter^1,*

¹Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München
²Pharmaceutical Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG; and
³Seidenader Maschinenbau GmbH (Körber AG)

↵*Correspondence: Building 0226, 23084, 42096 Wuppertal, Germany; E-mail: julian.lenger{at}bayer.com or Butenandtstr. 5, Building B, 81377 Munich, Germany; E-mail: gerhard.winter{at}cup.uni-muenchen.de

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100% Control of Controlled Ice Nucleation Vials by Camera-Supported Optical Inspection in Freeze-Drying

Julian H. Lenger, Raimund Geidobler, Werner Halbinger, Ingo Presser, Gerhard Winter

PDA Journal of Pharmaceutical Science and Technology Mar 2022, 76 (2) 120-135; DOI: 10.5731/pdajpst.2020.012575

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100% Control of Controlled Ice Nucleation Vials by Camera-Supported Optical Inspection in Freeze-Drying

Julian H. Lenger, Raimund Geidobler, Werner Halbinger, Ingo Presser, Gerhard Winter

PDA Journal of Pharmaceutical Science and Technology Mar 2022, 76 (2) 120-135; DOI: 10.5731/pdajpst.2020.012575

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Keywords

Lyophilization
Freeze-drying
Controlled nucleation
Inspection
Morphology
Protein

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