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Research ArticleResearch

Advances in Large Volume Subcutaneous Injections: A Pilot Tolerability Study of an Innovative Needle-Free Injection Platform

E. Lynne Kelley, Andrea Fernandes, Marc Pelletier, Eri A. Takami, Christine Emery, Bobby Dyer, Mary V. Jacoski, Valery Lozko, Bart Burgess and Richard H. Smith
PDA Journal of Pharmaceutical Science and Technology November 2022, 76 (6) 474-484; DOI: https://doi.org/10.5731/pdajpst.2021.012670
E. Lynne Kelley
Portal Instruments, Cambridge, MA
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Andrea Fernandes
Portal Instruments, Cambridge, MA
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Marc Pelletier
Portal Instruments, Cambridge, MA
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Eri A. Takami
Portal Instruments, Cambridge, MA
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Christine Emery
Portal Instruments, Cambridge, MA
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Bobby Dyer
Portal Instruments, Cambridge, MA
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Mary V. Jacoski
Portal Instruments, Cambridge, MA
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Valery Lozko
Portal Instruments, Cambridge, MA
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Bart Burgess
Portal Instruments, Cambridge, MA
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Richard H. Smith
Portal Instruments, Cambridge, MA
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  • For correspondence: rick.smith@portalinstruments.com
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Article Information

vol. 76 no. 6 474-484
DOI 
https://doi.org/10.5731/pdajpst.2021.012670
PubMed 
35296562

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online December 2, 2022.

Article Versions

  • previous version (March 16, 2022 - 13:32).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© PDA, Inc. 2022

Author Information

  1. E. Lynne Kelley,
  2. Andrea Fernandes,
  3. Marc Pelletier,
  4. Eri A. Takami,
  5. Christine Emery,
  6. Bobby Dyer,
  7. Mary V. Jacoski,
  8. Valery Lozko,
  9. Bart Burgess and
  10. Richard H. Smith*
  1. Portal Instruments, Cambridge, MA
  1. ↵*Corresponding Author: Portal Instruments, 190 5th St., Cambridge, MA 2141; E-mail: rick.smith{at}portalinstruments.com
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  • Towards more tolerable subcutaneous administration: Review of contributing factors for improving combination product design
    Neil Mathias, Sylvain Huille, Marie Picci, Robert P. Mahoney, Ronald J. Pettis, Brian Case, Bernhard Helk, David Kang, Ronak Shah, Junchi Ma, Deep Bhattacharya, Yogita Krishnamachari, Dany Doucet, Nathalie Maksimovikj, Sahab Babaee, Patrick Garidel, Reza Esfandiary, Rajesh Gandhi
    Advanced Drug Delivery Reviews 2024 209
  • Large volume subcutaneous delivery using multi-orifice jet injection
    James W. McKeage, Andrew Z.H. Tan, Andrew J. Taberner
    International Journal of Pharmaceutics 2024 649
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PDA Journal of Pharmaceutical Science and Technology: 76 (6)
PDA Journal of Pharmaceutical Science and Technology
Vol. 76, Issue 6
November/December 2022
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Advances in Large Volume Subcutaneous Injections: A Pilot Tolerability Study of an Innovative Needle-Free Injection Platform
E. Lynne Kelley, Andrea Fernandes, Marc Pelletier, Eri A. Takami, Christine Emery, Bobby Dyer, Mary V. Jacoski, Valery Lozko, Bart Burgess, Richard H. Smith
PDA Journal of Pharmaceutical Science and Technology Nov 2022, 76 (6) 474-484; DOI: 10.5731/pdajpst.2021.012670

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Advances in Large Volume Subcutaneous Injections: A Pilot Tolerability Study of an Innovative Needle-Free Injection Platform
E. Lynne Kelley, Andrea Fernandes, Marc Pelletier, Eri A. Takami, Christine Emery, Bobby Dyer, Mary V. Jacoski, Valery Lozko, Bart Burgess, Richard H. Smith
PDA Journal of Pharmaceutical Science and Technology Nov 2022, 76 (6) 474-484; DOI: 10.5731/pdajpst.2021.012670
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Keywords

  • Needle-free injector
  • Pain
  • Preference
  • Subcutaneous injection
  • Drug delivery

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