CPV of the Future: AI-Powered Continued Process Verification for Bioreactor Processes

Andrej Ondracka; Arnau Gasset; Xavier García-Ortega; David Hubmayr; Joeri van Wijngaarden; José Luis Montesinos-Seguí; Francisco Valero; Toni Manzano

doi:10.5731/pdajpst.2021.012665

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CPV of the Future: AI-Powered Continued Process Verification for Bioreactor Processes

Andrej Ondracka, Arnau Gasset, Xavier García-Ortega, David Hubmayr, Joeri van Wijngaarden, José Luis Montesinos-Seguí, Francisco Valero and Toni Manzano

PDA Journal of Pharmaceutical Science and Technology May 2023, 77 (3) 146-165; DOI: https://doi.org/10.5731/pdajpst.2021.012665

Andrej Ondracka

1Aizon, Córcega 301, 08008 Barcelona, Spain;

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Arnau Gasset

2Department of Chemical, Biological and Environmental Engineering, School of Engineering, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain;

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Xavier García-Ortega

3QuBilab, Departament de Biociències, Facultat de Ciències i Tecnologia, Universitat de Vic – Universitat Central de Catalunya, Vic, Spain; and

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David Hubmayr

4Process Development & Breakthrough Technologies R&D, CSL Behring AG, Wankdorfstrasse 10, 3014 Bern, Switzerland

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Joeri van Wijngaarden

1Aizon, Córcega 301, 08008 Barcelona, Spain;

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José Luis Montesinos-Seguí

2Department of Chemical, Biological and Environmental Engineering, School of Engineering, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain;

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Francisco Valero

2Department of Chemical, Biological and Environmental Engineering, School of Engineering, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain;

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Toni Manzano

1Aizon, Córcega 301, 08008 Barcelona, Spain;

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For correspondence: toni.manzano@aizon.ai

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vol. 77 no. 3 146-165

DOI

https://doi.org/10.5731/pdajpst.2021.012665

PubMed

36122916

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online June 8, 2023.

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previous version (September 19, 2022 - 04:02).
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Author Information

Andrej Ondracka¹,^#,
Arnau Gasset²,^#,
Xavier García-Ortega³,
David Hubmayr⁴,
Joeri van Wijngaarden¹,
José Luis Montesinos-Seguí²,
Francisco Valero² and
Toni Manzano¹,*

¹Aizon, Córcega 301, 08008 Barcelona, Spain;
²Department of Chemical, Biological and Environmental Engineering, School of Engineering, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain;
³QuBilab, Departament de Biociències, Facultat de Ciències i Tecnologia, Universitat de Vic – Universitat Central de Catalunya, Vic, Spain; and
⁴Process Development & Breakthrough Technologies R&D, CSL Behring AG, Wankdorfstrasse 10, 3014 Bern, Switzerland

↵*Corresponding Author: Aizon, Córcega 301, 08008 Barcelona, Spain; Telephone:+34 93627454605; E-mail: toni.manzano{at}aizon.ai

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CPV of the Future: AI-Powered Continued Process Verification for Bioreactor Processes

Andrej Ondracka, Arnau Gasset, Xavier García-Ortega, David Hubmayr, Joeri van Wijngaarden, José Luis Montesinos-Seguí, Francisco Valero, Toni Manzano

PDA Journal of Pharmaceutical Science and Technology May 2023, 77 (3) 146-165; DOI: 10.5731/pdajpst.2021.012665

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CPV of the Future: AI-Powered Continued Process Verification for Bioreactor Processes

Andrej Ondracka, Arnau Gasset, Xavier García-Ortega, David Hubmayr, Joeri van Wijngaarden, José Luis Montesinos-Seguí, Francisco Valero, Toni Manzano

PDA Journal of Pharmaceutical Science and Technology May 2023, 77 (3) 146-165; DOI: 10.5731/pdajpst.2021.012665

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Keywords

Bioprocess engineering
Bioreactor
Pichia pastoris
Artificial intelligence (AI)
machine learning
Anomaly detection
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