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Research ArticleResearch

In Silico Assessment of Biomolecule Reactivity with Leachables

Candice Johnson, Douglas Kiehl, Piet Christiaens, Ferran Sancho Jodar, Ruud Cuyvers, Arianna Bassan, Lisa Beilke, Joel P. Bercu, Thomas Costelloe, Kevin P. Cross, Andrew Feilden, Ron Filler, Maria Fátima Lucas, Melisa J. Masuda-Herrera, Mona Moghimi, Nick Morley, Diane Paskiet, Manuela Pavan, Julia Pletz, M. Vijayaraj Reddy, Christopher J. Waine and Glenn J. Myatt
PDA Journal of Pharmaceutical Science and Technology May 2024, 78 (3) 214-236; DOI: https://doi.org/10.5731/pdajpst.2022.012818
Candice Johnson
1Instem, 1393 Dublin Road, Columbus, OH 43215;
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  • For correspondence: candice.johnson@instem.com
Douglas Kiehl
2Eli Lilly and Company, Indianapolis, IN 46285;
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Piet Christiaens
3Nelson Labs, Romeinsestraat 12, 3001 Heverlee, Belgium;
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Ferran Sancho Jodar
4Zymvol Biomodeling, Carrer Pau Claris, 94, 08010 Barcelona, Spain;
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Ruud Cuyvers
3Nelson Labs, Romeinsestraat 12, 3001 Heverlee, Belgium;
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Arianna Bassan
5Innovatune, Via Giulio Zanon 130/D, 35129 Padova, Italy;
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Lisa Beilke
6Toxicology Solutions, Inc., Marana, AZ 85658;
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Joel P. Bercu
7Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404;
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Thomas Costelloe
8IMIHGOM B.V., Galileiweg 8, 2333 BD Leiden, The Netherlands;
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Kevin P. Cross
1Instem, 1393 Dublin Road, Columbus, OH 43215;
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Andrew Feilden
9BicycleTx Ltd, Cambridge CB21 6GS, United Kingdom;
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Ron Filler
10Drug Development Consultants, LLC, StoneBridge Farm, 15 Elizabeth Lane, Bedminster, NJ 07921;
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Maria Fátima Lucas
4Zymvol Biomodeling, Carrer Pau Claris, 94, 08010 Barcelona, Spain;
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Melisa J. Masuda-Herrera
7Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404;
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Mona Moghimi
8IMIHGOM B.V., Galileiweg 8, 2333 BD Leiden, The Netherlands;
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Nick Morley
11Element Materials Technology, Manchester, M23 9BE, United Kingdom;
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Diane Paskiet
12West Pharmaceutical Services, Inc., 530 Herman O. West Drive, Exton, PA 19341;
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Manuela Pavan
5Innovatune, Via Giulio Zanon 130/D, 35129 Padova, Italy;
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Julia Pletz
13Exponent International Ltd., Nauenstrasse 67, 4052 Basel, Switzerland;
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M. Vijayaraj Reddy
14Merck & Co., Inc., West Point, PA 19486; and
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Christopher J. Waine
15Bibra Toxicology Advice and Consulting, Wallington, Surrey, United Kingdom
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Glenn J. Myatt
1Instem, 1393 Dublin Road, Columbus, OH 43215;
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PDA Journal of Pharmaceutical Science and Technology: 78 (3)
PDA Journal of Pharmaceutical Science and Technology
Vol. 78, Issue 3
May/June 2024
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In Silico Assessment of Biomolecule Reactivity with Leachables
Candice Johnson, Douglas Kiehl, Piet Christiaens, Ferran Sancho Jodar, Ruud Cuyvers, Arianna Bassan, Lisa Beilke, Joel P. Bercu, Thomas Costelloe, Kevin P. Cross, Andrew Feilden, Ron Filler, Maria Fátima Lucas, Melisa J. Masuda-Herrera, Mona Moghimi, Nick Morley, Diane Paskiet, Manuela Pavan, Julia Pletz, M. Vijayaraj Reddy, Christopher J. Waine, Glenn J. Myatt
PDA Journal of Pharmaceutical Science and Technology May 2024, 78 (3) 214-236; DOI: 10.5731/pdajpst.2022.012818

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In Silico Assessment of Biomolecule Reactivity with Leachables
Candice Johnson, Douglas Kiehl, Piet Christiaens, Ferran Sancho Jodar, Ruud Cuyvers, Arianna Bassan, Lisa Beilke, Joel P. Bercu, Thomas Costelloe, Kevin P. Cross, Andrew Feilden, Ron Filler, Maria Fátima Lucas, Melisa J. Masuda-Herrera, Mona Moghimi, Nick Morley, Diane Paskiet, Manuela Pavan, Julia Pletz, M. Vijayaraj Reddy, Christopher J. Waine, Glenn J. Myatt
PDA Journal of Pharmaceutical Science and Technology May 2024, 78 (3) 214-236; DOI: 10.5731/pdajpst.2022.012818
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Keywords

  • Computational methods
  • Covalent interaction
  • Biomolecule active pharmaceutical ingredients
  • Monoclonal antibodies
  • Predictive methods
  • Extractables
  • Leachables

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