Filling of High-Concentration Monoclonal Antibody Formulations: Investigating Underlying Mechanisms Impacting Precision of Low-Volume Fill by Peristaltic Pump

Wendy Shieu; Dax Lamar; Oliver Boris Stauch; Yuh-Fun Maa

doi:10.5731/pdajpst.2015.005926

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Filling of High-Concentration Monoclonal Antibody Formulations: Investigating Underlying Mechanisms Impacting Precision of Low-Volume Fill by Peristaltic Pump

Wendy Shieu, Dax Lamar, Oliver Boris Stauch and Yuh-Fun Maa

PDA Journal of Pharmaceutical Science and Technology January 2016, pdajpst.2015.005926; DOI: https://doi.org/10.5731/pdajpst.2015.005926

Wendy Shieu

Genentech

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For correspondence: shieu.wendy@gene.com

Dax Lamar

Genentech

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For correspondence: lamar.dax@gene.com

Oliver Boris Stauch

Genentech

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For correspondence: staucho@gene.com

Yuh-Fun Maa

Genentech

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For correspondence: maay@gene.com

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pdajpst.2015.005926

DOI

https://doi.org/10.5731/pdajpst.2015.005926

PubMed

26797970

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Received September 28, 2015
Accepted December 22, 2015
Published online January 21, 2016.

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Author Information

Wendy Shieu (shieu.wendy{at}gene.com),
Dax Lamar (lamar.dax{at}gene.com),
Oliver Boris Stauch (staucho{at}gene.com) and
Yuh-Fun Maa 1 (maay{at}gene.com)

Genentech

↵* Corresponding author; email: maay{at}gene.com

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Filling of High-Concentration Monoclonal Antibody Formulations: Investigating Underlying Mechanisms Impacting Precision of Low-Volume Fill by Peristaltic Pump

Wendy Shieu, Dax Lamar, Oliver Boris Stauch, Yuh-Fun Maa

PDA Journal of Pharmaceutical Science and Technology Jan 2016, pdajpst.2015.005926; DOI: 10.5731/pdajpst.2015.005926

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Filling of High-Concentration Monoclonal Antibody Formulations: Investigating Underlying Mechanisms Impacting Precision of Low-Volume Fill by Peristaltic Pump

Wendy Shieu, Dax Lamar, Oliver Boris Stauch, Yuh-Fun Maa

PDA Journal of Pharmaceutical Science and Technology Jan 2016, pdajpst.2015.005926; DOI: 10.5731/pdajpst.2015.005926

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Keywords

Fill weight precision
High concentration monoclonal antibody
Liquid/nozzle interactions
Peristaltic pump
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