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Insights from a Thermodynamic Study and Its Implications on the Freeze Drying of Pharmaceutical Solutions Having Water and Tert-Butyl Alcohol as a Co-Solvent

Jee-Ching Wang, Roberto Bruttini and Athanasios I Liapis
PDA Journal of Pharmaceutical Science and Technology January 2019, pdajpst.2018.009209; DOI: https://doi.org/10.5731/pdajpst.2018.009209
Jee-Ching Wang
1 Missouri University of Science and Technology;
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  • For correspondence: jcwang@mst.edu
Roberto Bruttini
2 Criofarma-Freeze Drying Equipment
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  • For correspondence: criofarma@tin.it
Athanasios I Liapis
1 Missouri University of Science and Technology;
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  • For correspondence: ail@mst.edu
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Article Information

pdajpst.2018.009209
DOI 
https://doi.org/10.5731/pdajpst.2018.009209
PubMed 
30651336

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Received June 29, 2018
  • Accepted January 9, 2019
  • Published online January 16, 2019.

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  • You are currently viewing a previous version of this article (January 16, 2019 - 07:46).
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Copyright & Usage 
Copyright © 2019, Parenteral Drug Association

Author Information

  1. Jee-Ching Wang1 (jcwang{at}mst.edu),
  2. Roberto Bruttini2 (criofarma{at}tin.it) and
  3. Athanasios I Liapis1,3 (ail{at}mst.edu)
  1. 1 Missouri University of Science and Technology;
  2. 2 Criofarma-Freeze Drying Equipment
  1. ↵* Corresponding author; email: ail{at}mst.edu

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  • Insight into Morphology Change of Chitin Microspheres using Tertiary Butyl Alcohol/H2O Binary System Freeze‐Drying Method
    Daofa Ying, Zhenggang Wang, Yiran Zheng, Jie Cai, Lina Zhang
    Macromolecular Rapid Communications 2021 42 3
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PDA Journal of Pharmaceutical Science and Technology: 79 (3)
PDA Journal of Pharmaceutical Science and Technology
Vol. 79, Issue 3
May/June 2025
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Insights from a Thermodynamic Study and Its Implications on the Freeze Drying of Pharmaceutical Solutions Having Water and Tert-Butyl Alcohol as a Co-Solvent
Jee-Ching Wang, Roberto Bruttini, Athanasios I Liapis
PDA Journal of Pharmaceutical Science and Technology Jan 2019, pdajpst.2018.009209; DOI: 10.5731/pdajpst.2018.009209

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Insights from a Thermodynamic Study and Its Implications on the Freeze Drying of Pharmaceutical Solutions Having Water and Tert-Butyl Alcohol as a Co-Solvent
Jee-Ching Wang, Roberto Bruttini, Athanasios I Liapis
PDA Journal of Pharmaceutical Science and Technology Jan 2019, pdajpst.2018.009209; DOI: 10.5731/pdajpst.2018.009209
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Keywords

  • Bulk diffusion
  • Freeze drying
  • Knudsen diffusion
  • Partial vapor pressures
  • Tert-butyl alcohol (TBA)
  • Thermodynamic modeling

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