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OtherResearch

Local Concentrating, not Shear Stress, that may Lead to Possible Instability of Protein Molecules during Syringe Injection: A Fluid Dynamic Study with Two-Phase Flow Model

Lei Xing, Yue Li and Tonglei Li
PDA Journal of Pharmaceutical Science and Technology January 2019, pdajpst.2018.009357; DOI: https://doi.org/10.5731/pdajpst.2018.009357
Lei Xing
Purdue University
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  • For correspondence: xing42@purdue.edu
Yue Li
Purdue University
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  • For correspondence: li1788@purdue.edu
Tonglei Li
Purdue University
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  • For correspondence: tonglei@purdue.edu
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Article Information

pdajpst.2018.009357
DOI 
https://doi.org/10.5731/pdajpst.2018.009357
PubMed 
30651339

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Received August 2, 2018
  • Accepted January 11, 2019
  • Published online January 16, 2019.

Article Versions

  • You are currently viewing a previous version of this article (January 16, 2019 - 07:46).
  • View the most recent version of this article
Copyright & Usage 
Copyright © 2019, Parenteral Drug Association

Author Information

  1. Lei Xing (xing42@purdue.edu),
  2. Yue Li (li1788@purdue.edu) and
  3. Tonglei Li1 (tonglei@purdue.edu)
  1. Purdue University
  1. ↵* Corresponding author; email: tonglei@purdue.edu

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PDA Journal of Pharmaceutical Science and Technology: 79 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 79, Issue 2
March/April 2025
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Local Concentrating, not Shear Stress, that may Lead to Possible Instability of Protein Molecules during Syringe Injection: A Fluid Dynamic Study with Two-Phase Flow Model
Lei Xing, Yue Li, Tonglei Li
PDA Journal of Pharmaceutical Science and Technology Jan 2019, pdajpst.2018.009357; DOI: 10.5731/pdajpst.2018.009357
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Keywords

  • aggregation
  • auto-injector
  • extensional flow
  • Protein formulation
  • two-phase flow
  • unfolding

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Local Concentrating, not Shear Stress, that may Lead to Possible Instability of Protein Molecules during Syringe Injection: A Fluid Dynamic Study with Two-Phase Flow Model
Lei Xing, Yue Li, Tonglei Li
PDA Journal of Pharmaceutical Science and Technology Jan 2019, pdajpst.2018.009357; DOI: 10.5731/pdajpst.2018.009357

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