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Hot Melt extrusion: An emerging technique for solubility enhancement of poorly water soluble drugs

Amit Chivate, Atul Dattatraya Garkal, Namdev Laxman Dhas and Dr. Tejal Amit Mehta
PDA Journal of Pharmaceutical Science and Technology February 2021, pdajpst.2019.011403; DOI: https://doi.org/10.5731/pdajpst.2019.011403
Amit Chivate
Institute of Pharmacy, Nirma University
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  • For correspondence: amitchivate@gmail.com
Atul Dattatraya Garkal
Institute of Pharmacy, Nirma University
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Namdev Laxman Dhas
Institute of Pharmacy, Nirma University
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  • For correspondence: namdevdhas89@gmail.com
Dr. Tejal Amit Mehta
Institute of Pharmacy, Nirma University
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  • For correspondence: tjshah3@gmail.com
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Abstract

Solubility of the drug is a significant aspect to be considered during manufacturing of pharmaceutical products. Poor aqueous solubility of drugs imparts depleted bioavailability. In this regard, several techniques are available for enhancing drug solubility or dissolution. However, only a few of them are scalable and industrially applicable. Hot-melt extrusion (HME) is one of such techniques that have been widely used in the industry. It is a single-step continuous manufacturing and scalable method that has emerged successful in improving the solubility of poorly soluble drugs. This review highlights the numerous pharmaceutical applications of HME such as formulations of sterile implants, taste masking of unpleasant drugs, co-crystallization, salt formation, sustained and controlled release of formulations, etc. It also describes various hydrophilic and hydrophobic carriers utilized in HME. This review also briefly discusses the recent advances in HME and gives an update on the currently marketed products. The opportunities and challenges in future development of pharmaceutical products by HME technique are also discussed herewith.

  • Hot-melt extrusion
  • Poorly water soluble drugs
  • Solid-dispersion
  • Solubility and dissolution enhancement
  • Received December 30, 2019.
  • Accepted January 6, 2021.
  • Copyright © 2021, Parenteral Drug Association

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PDA Journal of Pharmaceutical Science and Technology: 75 (1)
PDA Journal of Pharmaceutical Science and Technology
Vol. 75, Issue 1
January/February 2021
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Hot Melt extrusion: An emerging technique for solubility enhancement of poorly water soluble drugs
Amit Chivate, Atul Dattatraya Garkal, Namdev Laxman Dhas, Dr. Tejal Amit Mehta
PDA Journal of Pharmaceutical Science and Technology Feb 2021, pdajpst.2019.011403; DOI: 10.5731/pdajpst.2019.011403

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Hot Melt extrusion: An emerging technique for solubility enhancement of poorly water soluble drugs
Amit Chivate, Atul Dattatraya Garkal, Namdev Laxman Dhas, Dr. Tejal Amit Mehta
PDA Journal of Pharmaceutical Science and Technology Feb 2021, pdajpst.2019.011403; DOI: 10.5731/pdajpst.2019.011403
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Keywords

  • Hot-melt extrusion
  • Poorly water soluble drugs
  • Solid-dispersion
  • Solubility and dissolution enhancement

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