Hot Melt extrusion: An emerging technique for solubility enhancement of poorly water soluble drugs

Amit Chivate; Atul Dattatraya Garkal; Namdev Laxman Dhas; Dr. Tejal Amit Mehta

doi:10.5731/pdajpst.2019.011403

Abstract

Solubility of the drug is a significant aspect to be considered during manufacturing of pharmaceutical products. Poor aqueous solubility of drugs imparts depleted bioavailability. In this regard, several techniques are available for enhancing drug solubility or dissolution. However, only a few of them are scalable and industrially applicable. Hot-melt extrusion (HME) is one of such techniques that have been widely used in the industry. It is a single-step continuous manufacturing and scalable method that has emerged successful in improving the solubility of poorly soluble drugs. This review highlights the numerous pharmaceutical applications of HME such as formulations of sterile implants, taste masking of unpleasant drugs, co-crystallization, salt formation, sustained and controlled release of formulations, etc. It also describes various hydrophilic and hydrophobic carriers utilized in HME. This review also briefly discusses the recent advances in HME and gives an update on the currently marketed products. The opportunities and challenges in future development of pharmaceutical products by HME technique are also discussed herewith.

Received December 30, 2019.
Accepted January 6, 2021.

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