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OtherTechnology/Application

Microbial Contamination in Water Systems

Fritz Roeder and Tim Sandle
PDA Journal of Pharmaceutical Science and Technology February 2022, pdajpst.2021.012636; DOI: https://doi.org/10.5731/pdajpst.2021.012636
Fritz Roeder
1 Merck Healthcare KGaA;
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  • For correspondence: fritz.roeder@merckgroup.com
Tim Sandle
2 Bio Products Laboratory Limited
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  • For correspondence: tim.sandle@bpl.co.uk
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Abstract

Abstract: The microbiological impurities are the most critical ones in a water system and are thus of special concern. In case of contamination of a purification unit or a distribution system, the user must react quickly. The authors have written down their experience and explain details about the typical microbiome of a water system. In addition, advice is given on how to remediate microbial contamination.

  • biofilm
  • microbiology
  • water
  • Received March 18, 2021.
  • Accepted January 20, 2022.
  • Copyright © 2022, Parenteral Drug Association

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PDA Journal of Pharmaceutical Science and Technology: 79 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 79, Issue 2
March/April 2025
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Microbial Contamination in Water Systems
Fritz Roeder, Tim Sandle
PDA Journal of Pharmaceutical Science and Technology Feb 2022, pdajpst.2021.012636; DOI: 10.5731/pdajpst.2021.012636

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Microbial Contamination in Water Systems
Fritz Roeder, Tim Sandle
PDA Journal of Pharmaceutical Science and Technology Feb 2022, pdajpst.2021.012636; DOI: 10.5731/pdajpst.2021.012636
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  • Mechanical Container Closure Integrity Test: A Method for Cartridge Systems
  • A Container Closure Integrity Test Method for Vials Stored at Cryogenic Conditions Using Headspace Oxygen Analysis
  • Best Practices for Microbial Challenge In-Use Studies to Evaluate the Microbial Growth Potential of Parenteral Biological Products; Industry and Regulatory Considerations
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Keywords

  • Biofilm
  • Microbiology
  • Water

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