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Characterizing extractables and leachables chemical space to support in silico toxicological hazard assessments

Candice Johnson, Arianna Bassan, Doug Kiehl, Diane Paskiet, Manuela Pavan, Patricia Parris, Geraldine Whelan, Anders Burild and Glenn J Myatt
PDA Journal of Pharmaceutical Science and Technology December 2023, pdajpst.2022.012819; DOI: https://doi.org/10.5731/pdajpst.2022.012819
Candice Johnson
1 Instem;
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  • For correspondence: candice.johnson@instem.com
Arianna Bassan
2 Innovatune;
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  • For correspondence: arianna.bassan@innovatune.com
Doug Kiehl
3 Eli Lilly;
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  • For correspondence: kiehl_douglas_e@lilly.com
Diane Paskiet
4 West Pharmaceutical Services;
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  • For correspondence: diane.paskiet@westpharma.com
Manuela Pavan
2 Innovatune;
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  • For correspondence: manuela.pavan@innovatune.com
Patricia Parris
5 Pfizer;
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  • For correspondence: patricia.parris@pfizer.com
Geraldine Whelan
6 GlaxoSmithKline;
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  • For correspondence: geraldine.b.whelan@gsk.com
Anders Burild
7 Novo Nordisk
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  • For correspondence: qabu@novonordisk.com
Glenn J Myatt
1 Instem;
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Article Information

pdajpst.2022.012819
DOI 
https://doi.org/10.5731/pdajpst.2022.012819
PubMed 
38942479

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Received December 15, 2022
  • Accepted December 5, 2023
  • Published online December 19, 2023.

Article Versions

  • You are currently viewing a previous version of this article (December 19, 2023 - 03:26).
  • View the most recent version of this article
Copyright & Usage 
Copyright © 2023, Parenteral Drug Association

Author Information

  1. Candice Johnson1 (candice.johnson{at}instem.com),
  2. Arianna Bassan2 (arianna.bassan{at}innovatune.com),
  3. Doug Kiehl3 (kiehl_douglas_e{at}lilly.com),
  4. Diane Paskiet4 (diane.paskiet{at}westpharma.com),
  5. Manuela Pavan2 (manuela.pavan{at}innovatune.com),
  6. Patricia Parris5 (patricia.parris{at}pfizer.com),
  7. Geraldine Whelan6 (geraldine.b.whelan{at}gsk.com),
  8. Anders Burild7 (qabu{at}novonordisk.com) and
  9. Glenn J Myatt1,8 (glenn.myatt{at}instem.com)
  1. 1 Instem;
  2. 2 Innovatune;
  3. 3 Eli Lilly;
  4. 4 West Pharmaceutical Services;
  5. 5 Pfizer;
  6. 6 GlaxoSmithKline;
  7. 7 Novo Nordisk
  1. ↵* Corresponding author; email: glenn.myatt{at}instem.com

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    Patricia Parris, Geraldine Whelan, Martyn L. Chilton, Claire Beaumont, Anders Burild, Uma Bruen, Courtney Callis, Jessica Graham, Natalia Kovalova, Elizabeth A. Martin, Melisa Masuda-Herrera, Carsten Worsøe, Anissa Alami, Joel Bercu, Dvir Doron, Kristen Dusenbury, Qiang Fu, Troy Griffin, Jedd Hillegass, Esther Johann, Agnes Koenig, Nina Macho, Alina Martirosyan, Kobi Oded, Constança Porredon Guarch, Matthew Schmitz, Brad Stanard, Eric Tien, Erika Udovic, Haiyan Xu, Maureen T. Cruz, Lee Nagao
    Regulatory Toxicology and Pharmacology 2025 157
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PDA Journal of Pharmaceutical Science and Technology: 79 (3)
PDA Journal of Pharmaceutical Science and Technology
Vol. 79, Issue 3
May/June 2025
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Characterizing extractables and leachables chemical space to support in silico toxicological hazard assessments
Candice Johnson, Arianna Bassan, Doug Kiehl, Diane Paskiet, Manuela Pavan, Patricia Parris, Geraldine Whelan, Anders Burild, Glenn J Myatt
PDA Journal of Pharmaceutical Science and Technology Dec 2023, pdajpst.2022.012819; DOI: 10.5731/pdajpst.2022.012819

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Characterizing extractables and leachables chemical space to support in silico toxicological hazard assessments
Candice Johnson, Arianna Bassan, Doug Kiehl, Diane Paskiet, Manuela Pavan, Patricia Parris, Geraldine Whelan, Anders Burild, Glenn J Myatt
PDA Journal of Pharmaceutical Science and Technology Dec 2023, pdajpst.2022.012819; DOI: 10.5731/pdajpst.2022.012819
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Keywords

  • Chemical class analysis
  • Computational assessments
  • Dermal sensitization
  • Extractables and leachables
  • Mutagenicity

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