Mechanical Container Closure Integrity Test: A Method for Cartridge Systems

Michael W Foubert; Benoit Lux; Julie Bourguard; Lucas Schultz; Meng John Zhao; Jason D Marlin; Matthew S Huser; Henri Hebting; Lei Li

doi:10.5731/pdajpst.2024.012941

OtherTechnology/Application

Mechanical Container Closure Integrity Test: A Method for Cartridge Systems

Michael W Foubert, Benoit Lux, Julie Bourguard, Lucas Schultz, Meng John Zhao, Jason D Marlin, Matthew S Huser, Henri Hebting and Lei Li

PDA Journal of Pharmaceutical Science and Technology April 2025, pdajpst.2024.012941; DOI: https://doi.org/10.5731/pdajpst.2024.012941

Michael W Foubert

Eli Lilly and Company

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For correspondence: foubertmw@lilly.com

Benoit Lux

Eli Lilly and Company

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Julie Bourguard

Eli Lilly and Company

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Lucas Schultz

Eli Lilly and Company

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Meng John Zhao

Eli Lilly and Company

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Jason D Marlin

Eli Lilly and Company

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Matthew S Huser

Eli Lilly and Company

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Henri Hebting

Eli Lilly and Company

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Lei Li

Eli Lilly and Company

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PDA Journal of Pharmaceutical Science and Technology

Vol. 79, Issue 2

March/April 2025

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Mechanical Container Closure Integrity Test: A Method for Cartridge Systems

Michael W Foubert, Benoit Lux, Julie Bourguard, Lucas Schultz, Meng John Zhao, Jason D Marlin, Matthew S Huser, Henri Hebting, Lei Li

PDA Journal of Pharmaceutical Science and Technology Apr 2025, pdajpst.2024.012941; DOI: 10.5731/pdajpst.2024.012941

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Mechanical Container Closure Integrity Test: A Method for Cartridge Systems

Michael W Foubert, Benoit Lux, Julie Bourguard, Lucas Schultz, Meng John Zhao, Jason D Marlin, Matthew S Huser, Henri Hebting, Lei Li

PDA Journal of Pharmaceutical Science and Technology Apr 2025, pdajpst.2024.012941; DOI: 10.5731/pdajpst.2024.012941

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Keywords

Parenteral drugs
constant force method
container-closure integrity
dye ingress test
mechanical container-closure integrity test
sterility

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Parenteral Drug Association, Inc.