Abstract
This manuscript reviews the similarities between death curves associated with ‘rogue’ biological indicator results in vapor phase hydrogen peroxide decontamination / sterilization processes and those expected from varying process conditions. The manuscript considers whether the perceived ‘rogue’ behavior of some biological indicators in these process may be the result of the phase differences. Consideration of ‘wet’ vs ‘dry’ processes are discussed and recommendations for process improvement to reduce failures are provided.
- Received November 22, 2024.
- Revision received May 22, 2025.
- Revision received April 3, 2025.
- Accepted May 28, 2025.
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