Abstract
The chemical stabilities of the vinca alkaloid anticancer drugs vinblastine, vincristine, and vindesine have been studied in three commonly used infusion fluids at 4 and 25°C. The infusion fluids were: 0.9% sodium chloride, 5% dextrose, and Ringer’s Lactate injection. Stability has been measured by using a stability-indicating high performance liquid chromatographic assay with ultraviolet detection. At 4°C no significant degradation of the vinca alkaloids occurred within a storage period of three weeks. The stability tests at 25°C also revealed that vinblastine, vincristine, and vindesine are stable (>95% remained) when stored for three weeks at this temperature in 5% dextrose. 0.9% sodium chloride, or Ringer’s Lactate infusion fluids.
- Received August 18, 1988.
- Accepted December 1, 1988.
- Copyright © Parenteral Drug Association. All rights reserved.
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