Abstract
The relationship between ultrasonic size reduction of liposomes characterized by gel filtration and the entrapped aqueous volume estimated from the dilution method was studied. The incorporation of cholesterol exhibited greater physical stability of the vesicles against ultrasonic vibration force. There was little difference of the entrapped aqueous volume between pure lecithin and lecithin-cholesterol (2:1) liposomes when the volume was expressed in terms of liters per mole of total lipid. The results imply that the cholesterol molecules incorporated participate in the formation of the concentric bilayer structure as much as the lecithin molecule does on the molecular volume basis. Entrapping efficiencies of liposomes consisting of pure lecithin and of lecithin-cholesterol (2:1) mixture were described for adriamycin. When cholesterol was incorporated, the loading capacity was roughly 2.5 times greater than that of the pure lecithin liposomes.
- Received May 19, 1981.
- Accepted September 16, 1981.
- Copyright © Parenteral Drug Association. All rights reserved.
PDA members receive access to all articles published in the current year and previous volume year. Institutional subscribers received access to all content. Log in below to receive access to this article if you are either of these.
If you are neither or you are a PDA member trying to access an article outside of your membership license, then you must purchase access to this article (below). If you do not have a username or password for JPST, you will be required to create an account prior to purchasing.
Full issue PDFs are for PDA members only.
Note to pda.org users
The PDA and PDA bookstore websites (www.pda.org and www.pda.org/bookstore) are separate websites from the PDA JPST website. When you first join PDA, your initial UserID and Password are sent to HighWirePress to create your PDA JPST account. Subsequent UserrID and Password changes required at the PDA websites will not pass on to PDA JPST and vice versa. If you forget your PDA JPST UserID and/or Password, you can request help to retrieve UserID and reset Password below.