Abstract
Highly anisotropic mixed ester membranes were tested against conventional mixed ester membranes to determine improvements, if any, inflow and throughput as a result of anisotropy. Because of inherent errors involved with the visual bubble point procedure, a combination of bubble point and mean flow pore was used in comparing these membranes. Water flows were found to be 50- to over 100% better in highly anisotropic membranes when compared to conventional membranes. Throughput studies indicated 2–3 times more volume per area using anisotropic membranes than with conventional membranes. Bacterial challenge tests using Pseudomonas dimunita and Serratia marcescens showed the same degree of retention for anisotropic membranes as with conventional membranes.
- Received June 23, 1981.
- Accepted November 2, 1981.
- Copyright © Parenteral Drug Association. All rights reserved.
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