Abstract
A determination was made of various chemical compounds leached from rubber stoppers into large volume parenteral solutions. Two kinds of rubber stoppers and 12 lots of large volume parenteral solutions with the same types of stoppers were evaluated. With the exception of furfural, the same chemical compounds were extracted from the parenteral solutions and from unused stoppers. Results showed that many chemical compounds are leached from rubber stoppers into large volume parenteral solutions and that some can cause harmful effects at certain concentration levels. Quantitative testing is needed to determine the levels of leached chemicals present in parenteral solutions.
- Received November 5, 1982.
- Accepted January 25, 1983.
- Copyright © Parenteral Drug Association. All rights reserved.
PDA members receive access to all articles published in the current year and previous volume year. Institutional subscribers received access to all content. Log in below to receive access to this article if you are either of these.
If you are neither or you are a PDA member trying to access an article outside of your membership license, then you must purchase access to this article (below). If you do not have a username or password for JPST, you will be required to create an account prior to purchasing.
Full issue PDFs are for PDA members only.
Note to pda.org users
The PDA and PDA bookstore websites (www.pda.org and www.pda.org/bookstore) are separate websites from the PDA JPST website. When you first join PDA, your initial UserID and Password are sent to HighWirePress to create your PDA JPST account. Subsequent UserrID and Password changes required at the PDA websites will not pass on to PDA JPST and vice versa. If you forget your PDA JPST UserID and/or Password, you can request help to retrieve UserID and reset Password below.