Abstract
The quaternary salt berberine can be delivered to the brain by injecting the lipoidal dihydroberberine, which is converted in vivo to berberine. The efflux from the brain of the berberine formed in situ is much slower than its rate of elimination from the general circulatory system. This inherent specificity for the brain of this redox delivery system can further be enhanced by slowly infusing the dihydroberberine instead of an i.v. bolus injection. It was found that by controlling infusion of dihydroberberine, the concentration of berberine (relative to its concentration after i.v. bolus) rose specifically in the brain while it fell in other tissues. It is suggested that a combination of the redox-delivery system with controlled infusion (or other controlled release techniques) will result in maximal brain-specific delivery.
- Received February 3, 1983.
- Accepted June 14, 1983.
- Copyright © Parenteral Drug Association. All rights reserved.
PDA members receive access to all articles published in the current year and previous volume year. Institutional subscribers received access to all content. Log in below to receive access to this article if you are either of these.
If you are neither or you are a PDA member trying to access an article outside of your membership license, then you must purchase access to this article (below). If you do not have a username or password for JPST, you will be required to create an account prior to purchasing.
Full issue PDFs are for PDA members only.
Note to pda.org users
The PDA and PDA bookstore websites (www.pda.org and www.pda.org/bookstore) are separate websites from the PDA JPST website. When you first join PDA, your initial UserID and Password are sent to HighWirePress to create your PDA JPST account. Subsequent UserrID and Password changes required at the PDA websites will not pass on to PDA JPST and vice versa. If you forget your PDA JPST UserID and/or Password, you can request help to retrieve UserID and reset Password below.
Log in using your username and password
Log in through your institution
Purchase access
patientACCESS
In This Issue
Jump to section
Related Articles
Cited By...
- No citing articles found.