Abstract
Aluminum(IH) has been shown to catalyze epinephrine degradation in lidocaine HCl with epinephrine solutions by increasing the rate of bisulfite addition. The rate accelerating effect of aluminum-(III) is attributed principally to its capacity to form a complex with epinephrine. The interaction of aluminum with epinephrine was investigated by spectrophotometric means and the results compared with those for other ligands; catechol and phenylephrine, and other metal ions; zinc(II) and copper(II). In acidic solutions, pH 4, there is evidence that aluminum chelates epinephrine through its catecholate structure in a 1:1 ratio. The logarithm of the formation constant (K1) for this complex was found to be 16.26 ± 0.02 by a spectrophotometric procedure and 16.12 ± 0.08 by an alternative potentiometricprocedure.
- Received January 18, 1983.
- Accepted June 9, 1983.
- Copyright © Parenteral Drug Association. All rights reserved.
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