Abstract
In an attempt to prolong the activity of Wy-41,747, a somatostatin analog that has been shown to improve diabetic control in type I human diabetics, the peptide was adsorbed on zinc phosphate. A flocculated suspension was produced that extended the growth hormone suppressing effects of Wy-4l, 747 in rats to at least 17 hr, compared to 2 hr when the peptide is administered dissolved in saline. A suspension prepared using somatostatin in place of Wy-41,747 was not flocculated and gave no prolongation of activity, suggesting that no adsorption occurred. The presence of histidine residues in Wy-41,747 that are not present in somatostatin is postulated to be the reason for the success of the formulation.
- Received August 14, 1984.
- Accepted November 14, 1984.
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