Abstract
The solubility of amphotericin B, a potent antifungal antibiotic, was determined in solvents deemed acceptable for use in i.v. formulations. A total of eighteen solvent mixtures (binary and ternary) were used in the solubility screen. The collected solubility data indicate that only two solvent systems, PEG 400/propylene glycol (50/50) and N,N-dimethylacetamide yielded an amphotericin B solubility > I mg/mL. The solubility of amphotericin B in the aprotic solvent N,N-dimethylacetamide was observed to dramatically increase from 7.6 to 152.4 mg/mL in the presence of added 6.0% w/v sodium deoxycholate. Surface tension and conductivity measurements indicate that the mechanism for this dramatic increase in the solubility of amphotericin B in the presence of added sodium deoxycholate is not micellar. Preliminary data suggest that a plausible explanation for the solubility enhancement in the presence of added sodium deoxycholate involves the formation of ion pairs.
- Received May 9, 1988.
- Accepted May 16, 1988.
- Copyright © Parenteral Drug Association. All rights reserved.
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