Quantitative Evaluation of the Stability and Delivery of lnterleukin-1 B by Infusion

Gary C. Visor; Kelly P. Tsai; Jane Duffy; Mary D. Miller; Tom Calderwood; Victoria M. Knepp

Abstract

The stability and delivery of IL-1β has been characterized in a polypropylene based syringe pump infusion system and in polyvinyl chloride based infusion bags, at concentrations ranging from 100 μg/ mL to I μg/mL. At higher concentrations (1μg/mL). minimal drug loss was observed in both systems. At low doses (100 μg/mL) in the syringe-pump system, the addition of 1% human serum albumin was necessary to prevent significant drug adsorption to the polypropylene drug reservoir.

Received June 9, 1989.
Accepted December 13, 1989.

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