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Research ArticleResearch Communication

Quantitative Evaluation of the Stability and Delivery of lnterleukin-1 B by Infusion

Gary C. Visor, Kelly P. Tsai, Jane Duffy, Mary D. Miller, Tom Calderwood and Victoria M. Knepp
PDA Journal of Pharmaceutical Science and Technology May 1990, 44 (3) 130-132;
Gary C. Visor
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Kelly P. Tsai
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Jane Duffy
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Mary D. Miller
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Tom Calderwood
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Victoria M. Knepp
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Abstract

The stability and delivery of IL-1β has been characterized in a polypropylene based syringe pump infusion system and in polyvinyl chloride based infusion bags, at concentrations ranging from 100 μg/ mL to I μg/mL. At higher concentrations (1μg/mL). minimal drug loss was observed in both systems. At low doses (100 μg/mL) in the syringe-pump system, the addition of 1% human serum albumin was necessary to prevent significant drug adsorption to the polypropylene drug reservoir.

  • Received June 9, 1989.
  • Accepted December 13, 1989.
  • Copyright © Parenteral Drug Association. All rights reserved.

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PDA Journal of Pharmaceutical Science and Technology
Vol. 44, Issue 3
May-June 1990
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Quantitative Evaluation of the Stability and Delivery of lnterleukin-1 B by Infusion
Gary C. Visor, Kelly P. Tsai, Jane Duffy, Mary D. Miller, Tom Calderwood, Victoria M. Knepp
PDA Journal of Pharmaceutical Science and Technology May 1990, 44 (3) 130-132;

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Quantitative Evaluation of the Stability and Delivery of lnterleukin-1 B by Infusion
Gary C. Visor, Kelly P. Tsai, Jane Duffy, Mary D. Miller, Tom Calderwood, Victoria M. Knepp
PDA Journal of Pharmaceutical Science and Technology May 1990, 44 (3) 130-132;
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