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Research ArticleTECHNOLOGY/APPLICATION

Practical Application of the Cake-Complete, Pore-Plugging Model for Sizing Normal Flow Filters

Jonathan T. Royce
PDA Journal of Pharmaceutical Science and Technology September 2009, 63 (5) 462-471;
Jonathan T. Royce
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Article Information

vol. 63 no. 5 462-471
PubMed 
20158051

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online September 24, 2009.

Copyright & Usage 
© PDA, Inc. 2009

Author Information

  1. Jonathan T. Royce
  1. GE Healthcare Bio-Sciences Corp., 14 Walkup Drive, Westborough, MA 01581
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    PDA Journal of Pharmaceutical Science and Technology: 63 (5)
    PDA Journal of Pharmaceutical Science and Technology
    Vol. 63, Issue 5
    September/October 2009
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    Jonathan T. Royce
    PDA Journal of Pharmaceutical Science and Technology Sep 2009, 63 (5) 462-471;

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    Jonathan T. Royce
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    • Article
      • Abstract
      • Introduction
      • Overview of the Cake-Complete Model
      • Application of the Cake-Complete Model to Constant Pressure Data Estimate of Capacity
      • Initial Estimate of the Initial Flux (J0)
      • Initial Estimate of the Complete Blocking Constant (Kb)
      • Initial Estimate of the Caking Constant (Kc)
      • Optimization and Bounding of Fitted Parameters
      • Solving for Filter Area Requirements
      • Application of the Cake-Complete Model to Constant Flow Data Estimate of Capacity
      • Calculation of Flux (J0)
      • Initial Estimate of the Initial Pressure Drop (P0)
      • Initial Estimates of the Complete Blocking Constant and Caking Constant (Kb and Kc)
      • Optimization and Bounding of Fitted Parameters
      • Solving for Filter Area Requirements
      • Conclusions
      • References
    • Figures & Data
    • Info & Metrics
    • References
    • PDF

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