Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
PDA Journal of Pharmaceutical Science and Technology
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
PDA Journal of Pharmaceutical Science and Technology

Advanced Search

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • Follow pda on Twitter
  • Visit PDA on LinkedIn
  • Visit pda on Facebook
Research ArticleResearch

Intravenous Administration of Recombinant Human IL-10 Suppresses the Development of Anti–Thy 1–Induced Glomerulosclerosis in Rats

H. Rachmawati, L. Beljaars, C. Reker-Smit, H. I. Bakker, A. M. Van Loenen-Weemaes, M. N. Lub-De Hooge and K. Poelstra
PDA Journal of Pharmaceutical Science and Technology March 2011, 65 (2) 116-130;
H. Rachmawati
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
L. Beljaars
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. Reker-Smit
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
H. I. Bakker
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. M. Van Loenen-Weemaes
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. N. Lub-De Hooge
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K. Poelstra
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. 1.↵
    1. Lee S.,
    2. Lee S.,
    3. Sharma K.
    The pathogenesis of fibrosis and renal disease in scleroderma: recent insights from glomerulosclerosis. Curr. Rheumatol. Rep. 2004, 6 (2), 141–148.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Hodson E. M.,
    2. Alexander S. I.
    Evaluation and management of steroid-sensitive nephritic syndrome. Curr. Opin. Pediatr. 2008, 20, 145–50.
    OpenUrlCrossRefPubMedWeb of Science
  3. 3.↵
    1. Brockman M. A.,
    2. Kwon D. S.,
    3. Tighe D. P.,
    4. Pavlik D. F.,
    5. Rosato P. C.,
    6. Sela J.,
    7. Porichis F.,
    8. Le Gall S.,
    9. Waring M. T.,
    10. Moss K.,
    11. Jessen H.,
    12. Pereyra F.,
    13. Kavanagh D. G.,
    14. Walker B. D.,
    15. Kaufmann D. E.
    IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood 2009, 114 (2), 346–356.
    OpenUrlAbstract/FREE Full Text
  4. 4.↵
    1. Schreiber S.,
    2. et al
    . Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Gastroenterology 2000, 119 (6), 1461.
    OpenUrlCrossRefPubMedWeb of Science
  5. 5.↵
    1. Friedrich M.,
    2. Docke W. D.,
    3. Klein A.,
    4. Philipp S.,
    5. Volk H. D.,
    6. Sterry W.,
    7. Asadullah K.
    Immunomodulation by interleukin-10 therapy decreases the incidence of relapse and prolongs the relapse-free interval in psoriasis. J. Invest. Dermatol. 2002, 118 (4), 672.
    OpenUrlCrossRefPubMed
  6. 6.↵
    1. Beamer G. L.,
    2. Flaherty D. K.,
    3. Assogba B. D.,
    4. Stromberg P.,
    5. Gonzalez-Juarrero M.,
    6. de Waal Malefyt R.,
    7. Vesosky B.,
    8. Turner J.
    Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice. J. Immunol. 2008, 181 (8), 5545.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. El-Shemi A. G.,
    2. Fujinaka H.,
    3. Matsuki A.,
    4. Kamiie J.,
    5. Kovalenko P.,
    6. Qu Z.,
    7. Bilim V.,
    8. Nishimoto G.,
    9. Yaoita E.,
    10. Yoshida Y.,
    11. Anegon I.,
    12. Yamamoto T.
    Suppression of experimental crescentic glomerulonephritis by interleukin-10 gene transfer. Kidney Int. 2004, 65 (4), 1280.
    OpenUrlCrossRefPubMedWeb of Science
  8. 8.↵
    1. Mu W.,
    2. et al
    . IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease. J. Am. Soc. Nephrol. 2005, 16 (12), 3651.
    OpenUrlAbstract/FREE Full Text
  9. 9.↵
    1. Rachmawati H.,
    2. Beljaars L.,
    3. Reker-Smit C.,
    4. van Loenen-Weemaes A. M.,
    5. Hagens W. I.,
    6. Meijer D. K. F.,
    7. Poelstra K.
    Pharmacokinetic and biodistribution profile of recombinant human interleukin-10 following intravenous administration in rats with extensive liver fibrosis. Pharm. Res. 2004, 21 (11), 2072.
    OpenUrlCrossRefPubMedWeb of Science
  10. 10.↵
    1. Bagchus W. M.,
    2. Hoedemaeker P. J.,
    3. Rozing J.,
    4. Bakker W. W.
    Acute glomerulonephritis after intravenous injection of monoclonal anti-thymocyte antibodies in the rat. Immunol. Lett. 1986, 12 (2–3), 109.
    OpenUrlCrossRefPubMed
  11. 11.↵
    1. Poelstra K.,
    2. Hardonk M. J.,
    3. Koudstaal J.,
    4. Bakker W. W.
    Intraglomerular platelet aggregation and experimental glomerulonephritis. Kidney Int. 1990, 37 (6), 1500.
    OpenUrlPubMedWeb of Science
  12. 12.↵
    1. Tsuboi Y.,
    2. Shankland S. J.,
    3. Grande J. P.,
    4. Walker H. J.,
    5. Johnson R. J.,
    6. Dousa T. P.
    Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV. J. Clin. Invest. 1996, 98 (2), 262.
    OpenUrlCrossRefPubMedWeb of Science
  13. 13.↵
    1. Wada Y.,
    2. Morioka T.,
    3. Oyanagi-Tanaka Y.,
    4. Yao J.,
    5. Suzuki Y.,
    6. Gejyo F.,
    7. Arakawa M.,
    8. Oite T.
    Impairment of vascular regeneration precedes progressive glomerulosclerosis in Anti–Thy 1 glomerulonephritis. Kidney Int. 2002, 61 (2), 432.
    OpenUrlCrossRefPubMedWeb of Science
  14. 14.↵
    1. Tomita M.,
    2. Koike H.,
    3. Han G. D.,
    4. Shimizu F.,
    5. Kawachi H.
    Decreased collagen-degrading activity could be a marker of prolonged mesangial matrix expansion. Clin. Exp. Nephrol. 2004, 8 (1), 17.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Makibayashi K.,
    2. Tatematsu M.,
    3. Hirata M.,
    4. Fukushima N.,
    5. Kusano K.,
    6. Ohashi S.,
    7. Abe H.,
    8. Kuze K.,
    9. Fukatsu A.,
    10. Kita T.,
    11. Doi T.
    A vitamin D analog ameliorates glomerular injury on rat glomerulonephritis. Am. J. Pathol. 2001, 158 (5), 1733.
    OpenUrlCrossRefPubMedWeb of Science
  16. 16.↵
    1. Koshikawa M.,
    2. Mukoyama M.,
    3. Mori K.,
    4. Suganami T.,
    5. Sawai K.,
    6. Yoshioka T.,
    7. Nagae T.,
    8. Yokoi H.,
    9. Kawachi H.,
    10. Shimizu F.,
    11. Sugawara A.,
    12. Nakao K.
    Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome. J. Am. Soc. Nephrol. 2005, 16 (9), 2690.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Haas M.,
    2. de Zeeuw D.,
    3. Van Zanten A.,
    4. Meijer D. K. F.
    Quantification of renal low molecular-weight protein handling in the intact rat. Kidney Int. 1993, 43, 949–954.
    OpenUrlPubMed
  18. 18.↵
    1. Sen N. P.,
    2. Donaldson B.
    Improved colorimetric method for determining nitrate and nitrate in foods. J. Assoc. Off. Anal. Chem. 1978, 61 (6): 1389–1394.
    OpenUrlPubMed
  19. 19.↵
    1. Ishizuka S.,
    2. Cunard R.,
    3. Poucell-Hatton S.,
    4. Wead L.,
    5. Lortie M.,
    6. Thomson S. C.,
    7. Gabbai F. B.,
    8. Satriano J.,
    9. Blantz R. C.
    Agmatine inhibits cell proliferation and improves renal function in anti-thy-1 glomerulonephritis. J. Am. Soc. Nephrol. 2000, 11 (12), 2256.
    OpenUrlAbstract/FREE Full Text
  20. 20.↵
    1. Gomis-Ruth F. X.,
    2. Gohlke U.,
    3. Betz M.,
    4. Knauper V.,
    5. Murphy G.,
    6. Lopez-Otin C.,
    7. Bode W.
    The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain. J. Mol. Biol. 1996, 264 (3), 556.
    OpenUrlCrossRefPubMedWeb of Science
  21. 21.↵
    1. Schnaper H. W.,
    2. Kopp J. B.,
    3. Poncelet A. C.,
    4. Hubchak S. C.,
    5. Stetler-Stevenson W. G.,
    6. Klotman P. E.,
    7. Kleinman H. K.
    Increased expression of extracellular matrix proteins and decreased expression of matrix proteases after serial passage of glomerular mesangial cells. J. Cell. Sci. 1996, 109 (Pt 10), 2521.
    OpenUrlAbstract/FREE Full Text
  22. 22.↵
    1. Atkins R. C.,
    2. Holdsworth S. R.,
    3. Glasgow E. F.,
    4. Matthews F. E.
    The macrophage in human rapidly progressive glomerulonephritis. Lancet 1976, 1 (7964), 830–832.
    OpenUrlPubMedWeb of Science
  23. 23.↵
    1. Ma F. Y.,
    2. Flanc R. S.,
    3. Tesch G. H.,
    4. Bennett B. L.,
    5. Friedman G. C.,
    6. Nikolic-Paterson D. J.
    Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab Invest. 2009, 89 (4), 470.
    OpenUrlCrossRefPubMedWeb of Science
  24. 24.↵
    1. Kaneko Y.,
    2. Shiozawa S.,
    3. Hora K.,
    4. Nakazawa K.
    Glomerulosclerosis develops in Thy-1 nephritis under persistent accumulation of macrophages. Pathol. Int. 2003, 53 (8), 507.
    OpenUrlPubMed
  25. 25.↵
    1. Robertson T. E.,
    2. Nikolic-Paterson D. J.,
    3. Tesch G. H.,
    4. Foti R. A.,
    5. Atkins R. C.,
    6. Chadban S. J.
    Role of interleukin-10 in rat mesangioproliferative glomerulonephritis. Nephrology 2003, 8 (1), 33.
    OpenUrlPubMed
  26. 26.↵
    1. Tesch G. H.,
    2. Lan H. Y.,
    3. Atkins R. C.,
    4. Nikolic-Paterson D. J.
    Role of interleukin-1 in mesangial cell proliferation and matrix deposition in experimental mesangioproliferative nephritis. Am. J. Pathol. 1997, 151 (1), 141.
    OpenUrlPubMedWeb of Science
  27. 27.↵
    1. Kaneko Y.,
    2. Nakazawa K.,
    3. Higuchi M.,
    4. Hora K.,
    5. Shigematsu H.
    Glomerular expression of alpha-smooth muscle actin reflects disease activity of IgA nephropathy. Pathol. Int. 2001, 51 (11), 833.
    OpenUrlCrossRefPubMed
  28. 28.↵
    1. Hsu C. C.,
    2. Lai S. C.
    Matrix metalloproteinase-2, -9 and -13 are involved in fibronectin degradation of rat lung granulomatous fibrosis caused by Angiostrongylus cantonensis. Int. J. Exp. Pathol. 2007, 88 (6), 437.
    OpenUrlCrossRefPubMedWeb of Science
  29. 29.↵
    1. Hernández Ríos M.,
    2. Sorsa T.,
    3. Obregón F.,
    4. Tervahartiala T.,
    5. Valenzuela M. A.,
    6. Pozo P.,
    7. Dutzan N.,
    8. Lesaffre E.,
    9. Molas M.,
    10. Gamonal J.
    Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade. J. Clin. Periodontol. 2009, 36 (12), 1011.
    OpenUrlCrossRefPubMed
PreviousNext
Back to top

In This Issue

PDA Journal of Pharmaceutical Science and Technology: 65 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 65, Issue 2
March/April 2011
  • Table of Contents
  • Index by Author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Intravenous Administration of Recombinant Human IL-10 Suppresses the Development of Anti–Thy 1–Induced Glomerulosclerosis in Rats
(Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology
(Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
2 + 5 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Intravenous Administration of Recombinant Human IL-10 Suppresses the Development of Anti–Thy 1–Induced Glomerulosclerosis in Rats
H. Rachmawati, L. Beljaars, C. Reker-Smit, H. I. Bakker, A. M. Van Loenen-Weemaes, M. N. Lub-De Hooge, K. Poelstra
PDA Journal of Pharmaceutical Science and Technology Mar 2011, 65 (2) 116-130;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Intravenous Administration of Recombinant Human IL-10 Suppresses the Development of Anti–Thy 1–Induced Glomerulosclerosis in Rats
H. Rachmawati, L. Beljaars, C. Reker-Smit, H. I. Bakker, A. M. Van Loenen-Weemaes, M. N. Lub-De Hooge, K. Poelstra
PDA Journal of Pharmaceutical Science and Technology Mar 2011, 65 (2) 116-130;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Conflict of Interest Declaration
    • Acknowledgements
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Quantitative and Qualitative Evaluation of Microorganism Profile Identified in Bioburden Analysis in a Biopharmaceutical Facility in Brazil: Criteria for Classification and Management of Results
  • Evaluation of Extreme Depyrogenation Conditions on the Surface Hydrolytic Resistance of Glass Containers for Pharmaceutical Use
  • A Holistic Approach for Filling Volume Variability Evaluation and Control with Statistical Tool
Show more Research

Similar Articles

Readers

  • About
  • Table of Content Alerts/Other Alerts
  • Subscriptions
  • Terms of Use
  • Contact Editors

Author/Reviewer Information

  • Author Resources
  • Submit Manuscript
  • Reviewers
  • Contact Editors

Parenteral Drug Association, Inc.

  • About
  • Advertising/Sponsorships
  • Events
  • PDA Bookstore
  • Press Releases

© 2025 PDA Journal of Pharmaceutical Science and Technology Print ISSN: 1079-7440  Digital ISSN: 1948-2124

Powered by HighWire