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PDA Journal of Pharmaceutical Science and Technology

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Research ArticleResearch

Investigating Liquid Leak from Pre-Filled Syringes upon Needle Shield Removal: Effect of Air Bubble Pressure

Edwin Chan, Yuh-Fun Maa, David Overcashier and Chung C. Hsu
PDA Journal of Pharmaceutical Science and Technology July 2011, 65 (4) 363-371; DOI: https://doi.org/10.5731/pdajpst.2011.00759
Edwin Chan
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Yuh-Fun Maa
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David Overcashier
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Chung C. Hsu
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References

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    1. Romacker M.,
    2. Shoenknecht T.
    The Rise of Prefilled Syringes from Niche Product to Primary Container of Choice: A Short History. Presented at PDA Conference “The Universe of Pre-filled Syringes and Injection Devices,” San Diego, USA, 2008. http://www.pda.org/prefilled2008 (accessed August 16, 2010).
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    . Development of a Prefilled Syringe: Filling of Pre-filled Syringes. Presented at PDA Europe Conference “The Universe of Pre-Filled Syringes & Injection Devices,” Venice, Italy, 2009.
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    1. Kinney H.,
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    A rational approach to determining the maximum allowable gas bubble inside a prefilled syringe to minimize stopper movement and protect product sterility. Drug Deliv. Technol. 2009, 9, 42– 47.
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    Lighthouse Instruments website, FMS-1400 Headspace Pressure/Moisture Analyzer, http://www.lighthouseinstruments.com/NewFiles/vacuum.html (accessed August 16, 2010).
  5. 5.↵
    1. Hamme R.,
    2. Emerson S.
    The solubility of neon, nitrogen and argon in distilled water and seawater. Deep Sea Research Part I: Oceanographic Research Papers 2004, 51 (11),1517– 1528.
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    1. Smith N.,
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    Solubility of natural gases in aqueous salt solutions. Geochimica et Cosmochimica Acta 1961, 24 (1–2),23– 31.
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  7. 7.↵
    1. Gevantman L. H.
    Solubility of Selected Gases in Water. In CRC Handbook, 86th ed.; CRC Press LLC: Boca Raton, Florida, 2004, pp 8-86– 8-87.
  8. 8.↵
    1. Masoudi R.,
    2. Tohidi B.,
    3. Danesh A.
    Modelling Gas Solubility in Saline Solution and Its Importance to IOR Gas Injection. Institute of Petroleum Engineering, Heriot-Watt University: Edinburgh, UK, 2000.
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In This Issue

PDA Journal of Pharmaceutical Science and Technology: 65 (4)
PDA Journal of Pharmaceutical Science and Technology
Vol. 65, Issue 4
July/August 2011
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Investigating Liquid Leak from Pre-Filled Syringes upon Needle Shield Removal: Effect of Air Bubble Pressure
Edwin Chan, Yuh-Fun Maa, David Overcashier, Chung C. Hsu
PDA Journal of Pharmaceutical Science and Technology Jul 2011, 65 (4) 363-371; DOI: 10.5731/pdajpst.2011.00759

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Investigating Liquid Leak from Pre-Filled Syringes upon Needle Shield Removal: Effect of Air Bubble Pressure
Edwin Chan, Yuh-Fun Maa, David Overcashier, Chung C. Hsu
PDA Journal of Pharmaceutical Science and Technology Jul 2011, 65 (4) 363-371; DOI: 10.5731/pdajpst.2011.00759
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  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results and Discussion
    • Conclusions
    • Conflict of Interest Declaration
    • Appendix I. Stopper Insertion Tool (not drawn to scale)
    • Appendix II. Solubility Profile of Different Gases in Water at 1 atm
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