Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
PDA Journal of Pharmaceutical Science and Technology
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
PDA Journal of Pharmaceutical Science and Technology

Advanced Search

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • Follow pda on Twitter
  • Visit PDA on LinkedIn
  • Visit pda on Facebook
OtherConference Proceeding

Theory and Practice of Conventional Adventitious Virus Testing

Jens-Peter Gregersen
PDA Journal of Pharmaceutical Science and Technology November 2011, 65 (6) 634-644; DOI: https://doi.org/10.5731/pdajpst.2011.00832
Jens-Peter Gregersen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: jens-peter.gregersen@novartis.com
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. 1.↵
    European Directorate for the Quality of Medicines (EDQM). Tests for extraneous agents in viral vaccines for human use. Chapter 2.6.16. European Pharmacopoeia 5.0, 2005.
  2. 2.↵
    Center for Biologics Evaluation and Research (CBER). Guidance for industry: Characterization and qualification of cell substrates and other biological materials used in the production of viral vaccines for infectious disease indications. Rockville, MD, USA, 2010.
  3. 3.↵
    1. Americo J. L.,
    2. Moss B.,
    3. Earl P. L.
    Identification of wild-derived inbred mouse strains highly susceptible to monkeypox virus infection for use as small animal models. J. Virol. 2010, 84 (16): 8172–8180.
    OpenUrlAbstract/FREE Full Text
  4. 4.↵
    1. Kraemer B.,
    2. Ruebmann P. K.,
    3. Duchow K.,
    4. Cussler K.
    Fremdvirusausschluß in Lebendimpfstoffen. ALTEX 1998, 15, 43–45.
    OpenUrlPubMed
  5. 5.↵
    1. Heiss B. L.,
    2. Maximova O. A.,
    3. Pletnev A. G.
    Insertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype. J. Virol. 2010, 85 (4), 1464–1472.
    OpenUrlPubMed
  6. 6.↵
    1. Bennett R. S.,
    2. Cress C. M.,
    3. Ward J. M.,
    4. Firestone C. Y.,
    5. Murphy B. R.,
    6. Whitehead. S. S.
    La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys. Virol. J. 2008, 5, 25.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Rong X.,
    2. Xiang R. L.,
    3. Chu M. P.,
    4. Wu R. Z.,
    5. Chen Q.,
    6. Xu Q.,
    7. Zhang Y. H.
    Effects of hemoglobin oxygenase-1 inhibitor zinc protoporphyrin IX on acute viral myocarditis in mice. Zhonghua Er Ke Za Zhi 2007, 45 (12), 893–897. [Article in Chinese. Detailed abstract available under http://www.ncbi.nlm.nih.gov/pubmed/18339274.]
    OpenUrlPubMed
  8. 8.↵
    1. Yauch L. E.,
    2. Shresta S.
    Mouse models of dengue virus infection and disease. Antiviral Res. 2008, 80 (2), 87–93.
    OpenUrlCrossRefPubMedWeb of Science
  9. 9.↵
    1. Tan G. K.,
    2. Ng J. K.,
    3. Trasti S. L.,
    4. Schul W.,
    5. Yip G.,
    6. Alonso S.
    A non mouse-adapted dengue virus strain as a new model of severe dengue infection in AG129 mice. PLoS. Negl. Trop. Dis. 2010, 27, e672.
    OpenUrl
  10. 10.↵
    1. Horzinek M. C.
    Haemagglutinationstest. Chapter 1.1.2.2. In: Kompendium der Allgemeinen Virologie, 2nd Ed.; Verlag Paul Parey, Berlin, 1985; p 24.
  11. 11.↵
    1. Mayr A.,
    2. Bachmann P.,
    3. Bibrack B.,
    4. Wittmann G.
    Haemagglutinationshemmungsreaktion (HAH). In Virologische Arbeitsmethoden; Band II, Chapter 2. G. Fischer Verlag: Stuttgart, New York, 1977; pp 207–223.
  12. 12.↵
    1. Barta V.,
    2. Springer W. T.,
    3. Millar D. L.
    A comparison of avian and mammalian cell cultures for the propagation of avian reovirus WVU 2937. Avian Dis. 1984, 28 (1), 216–223.
    OpenUrlCrossRefPubMedWeb of Science
  13. 13.↵
    1. Sahu S. P.,
    2. Olson N. O.
    Comparison of characteristics of avian reovirus isolated from the digestive and respiratory tract with virus isolated from the synovia. Am. J. Vet. Res. 1975, 36 (6), 847–850.
    OpenUrlPubMed
  14. 14.↵
    1. Jones R. C.,
    2. Al Afaleq A. I.
    Different sensitivities of Vero cells from two sources to avian reoviruses. Res. Vet. Sci. 1990, 48 (3), 379–380.
    OpenUrlPubMed
  15. 15.↵
    1. Heilbronn R.,
    2. Albrecht I.,
    3. Stephan S.,
    4. Bürkle A.,
    5. zur Hausen H.
    Human cytomegalovirus induces JC virus DNA replication in human fibroblasts. Proc. Natl. Acad. Sci. USA 1993, 90 (23), 11406–11410.
    OpenUrlAbstract/FREE Full Text
  16. 16.↵
    1. Duizer E.,
    2. Schwab K. J.,
    3. Neill F. H.,
    4. Atmar R. L.,
    5. Koopmans M. P. G.,
    6. Estes M. K.
    Laboratory efforts to cultivate noroviruses. J. Gen. Virol. 2004, 85, 79–87.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Malik Y. S.,
    2. Maherchandani S.,
    3. Allwood P. B.,
    4. Goyal S. M.
    Evaluation of animal origin cell cultures for in vitro cultivation of noroviruses. J. Appl. Res. 2005, 5 (2), 312–317.
    OpenUrl
  18. 18.↵
    1. Moore W. A.
    Experience in cell line testing. Dev. Biol. Stand. 1992, 76, 51–56.
    OpenUrlPubMed
  19. 19.↵
    1. Kravchenko A. T.,
    2. Tsetlin E. M.,
    3. Omelchenko T. N.
    Rational method of producing sera with high titers of virus neutralizing antibodies. Zh. Mikrobiol. Epidemiol. Immunobiol. 1997, 1, 41–45.
    OpenUrl
  20. 20.↵
    European Directorate for the Quality of Medicines (EDQM). Influenza vaccine (surface antigen, inactivated, prepared in cell cultures). Monograph 2149, Supp. 5.5, European Pharmacopoeia, Strasbourg, 2006.
  21. 21.↵
    1. Ill C. R.,
    2. Dehghani H.
    Risk reduction in biotherapeutic products. Curr. Opin. Drug Discov. Devel. 2009, 12 (2), 296–304.
    OpenUrlPubMed
  22. 22.↵
    1. Onions D.,
    2. Kolman J.
    Massively parallel sequencing, a new method for detecting adventitous agents. Biologicals 2010, 38 (3), 377–380.
    OpenUrlPubMed
  23. 23.↵
    1. Victoria J. G.,
    2. Wang C.,
    3. Jones M. S.,
    4. Jaing C.,
    5. McLoughlin K.,
    6. Gardner S.,
    7. Delwart E. L.
    Viral nucleic acids in live-attenuated vaccines: detection of minority variants and an adventitious virus. J. Virol. 2010, 84 (12), 6033–6040.
    OpenUrlAbstract/FREE Full Text
PreviousNext
Back to top

In This Issue

PDA Journal of Pharmaceutical Science and Technology: 65 (6)
PDA Journal of Pharmaceutical Science and Technology
Vol. 65, Issue 6
November/December 2011
  • Table of Contents
  • Index by Author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Theory and Practice of Conventional Adventitious Virus Testing
(Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology
(Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
12 + 4 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Theory and Practice of Conventional Adventitious Virus Testing
Jens-Peter Gregersen
PDA Journal of Pharmaceutical Science and Technology Nov 2011, 65 (6) 634-644; DOI: 10.5731/pdajpst.2011.00832

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Theory and Practice of Conventional Adventitious Virus Testing
Jens-Peter Gregersen
PDA Journal of Pharmaceutical Science and Technology Nov 2011, 65 (6) 634-644; DOI: 10.5731/pdajpst.2011.00832
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Conventional Test Schemes for Extraneous Viruses
    • Detectability of Viruses by Conventional Tests
    • Unspecific Side Effects and Questionable Results
    • Animal Numbers Needed
    • Time and Cost of Conventional Testing
    • Neutralization of the Virus Contained in Seed Lots and Virus Harvests
    • Applicability of Conventional Tests for Rapidly Changing Viral Seeds
    • Conclusions on Conventional Test Regimes
    • Alternative Methods and Strategies
    • Conflict of Interest Statement
    • Acknowledgments
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

Conference Proceeding

  • Proceedings of the 2017 Viral Clearance Symposium: Conclusion
  • Proceedings of the 2017 Viral Clearance Symposium, Session 1.2: Upstream Mitigation, Part 2—Virus Barrier Filter and HTST
  • Proceedings of the 2017 Viral Clearance Symposium, Session 3: Resin Lifetime
Show more Conference Proceeding

Plenary Session 5: Viral Testing: Existing Assays and Emerging Technologies

  • Current Testing Methods and Challenges for Detection of Adventitious Viruses
  • Overview of Emerging Technologies To Detect Adventitious Agents
Show more Plenary Session 5: Viral Testing: Existing Assays and Emerging Technologies

Paper

  • Current Testing Methods and Challenges for Detection of Adventitious Viruses
  • Overview of Emerging Technologies To Detect Adventitious Agents
  • Regulatory Approaches for Control of Viral Contamination of Vaccines
Show more Paper

Similar Articles

Readers

  • About
  • Table of Content Alerts/Other Alerts
  • Subscriptions
  • Terms of Use
  • Contact Editors

Author/Reviewer Information

  • Author Resources
  • Submit Manuscript
  • Reviewers
  • Contact Editors

Parenteral Drug Association, Inc.

  • About
  • Advertising/Sponsorships
  • Events
  • PDA Bookstore
  • Press Releases

© 2025 PDA Journal of Pharmaceutical Science and Technology Print ISSN: 1079-7440  Digital ISSN: 1948-2124

Powered by HighWire