Abstract
CONFERENCE PROCEEDING Proceedings of the PDA/FDA Adventitious Viruses in Biologics: Detection and Mitigation Strategies Workshop in Bethesda, MD, USA; December 1–3, 2010
Guest Editors: Arifa Khan (Bethesda, MD), Patricia Hughes (Bethesda, MD) and Michael Wiebe (San Francisco, CA)
We designed the Lawrence Livermore Microbial Detection Array (LLMDA), which contains 388,000 DNA probes. This array can detect any sequenced viruses or bacteria within 24 h. In addition, the oligonucleotide probes were selected to enable detection of novel, divergent species with homology to sequenced organisms. We recently used this array to identify an adventitious virus from a vaccine product. We have also used this array to detect viral and bacterial infections from various human clinical samples. Broad-spectrum microbial detection microarrays are efficient and cost-effective tools to rapidly screen cell bank samples, raw materials, vaccine samples, and clinical samples to ensure drug, food, and health safety in the United States and worldwide.
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- Article
- Abstract
- Introduction
- Current Pathogen Detection Techniques
- LLMDA Probe Design for Broad-Spectrum Detection of Viruses and Bacteria
- LLMDA Processing and Analysis
- Identification of Adventitious Agents from Vaccines Using the LLMDA
- Clinical Diagnostic Applications of LLMDA
- Potential of Microarray Technologies for Quality Control of Biological Material
- Advantages and Limitations of Microarrays
- Summary
- Conflict of Interest Declaration
- Acknowledgments
- References
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