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Research ArticleResearch

Information Processing: Rate-Based Investigation of Cell Physiological Changes along Design Space Development

Patrick Sagmeister, Patrick Wechselberger and Christoph Herwig
PDA Journal of Pharmaceutical Science and Technology November 2012, 66 (6) 526-541; DOI: https://doi.org/10.5731/pdajpst.2012.00889
Patrick Sagmeister
Vienna University of Technology, Institute of Chemical Engineering, Research Area Biochemical Engineering, Vienna, Austria
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Patrick Wechselberger
Vienna University of Technology, Institute of Chemical Engineering, Research Area Biochemical Engineering, Vienna, Austria
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Christoph Herwig
Vienna University of Technology, Institute of Chemical Engineering, Research Area Biochemical Engineering, Vienna, Austria
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  • For correspondence: christoph.herwig@tuwien.ac.at
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Article Information

vol. 66 no. 6 526-541
DOI 
https://doi.org/10.5731/pdajpst.2012.00889
PubMed 
23183649

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online November 26, 2012.

Copyright & Usage 
© PDA, Inc. 2012

Author Information

  1. Patrick Sagmeister,
  2. Patrick Wechselberger and
  3. Christoph Herwig*
  1. Vienna University of Technology, Institute of Chemical Engineering, Research Area Biochemical Engineering, Vienna, Austria
  1. ↵* Correspondence author: Christoph Herwig, Vienna University of Technology, Institute of Chemical Engineering, Research Area Biochemical Engineering, Gumpendorfer Straße 1a, A-1060 Vienna, Austria. Tel.: +43 1 58801 166400. E-mail: christoph.herwig{at}tuwien.ac.at
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  • A novel real‐time method to estimate volumetric mass biodensity based on the combination of dielectric spectroscopy and soft‐sensors
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  • Controlling the specific growth rate via biomass trend regulation in filamentous fungi bioprocesses
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    Journal of Biotechnology 2015 207
  • High level extracellular production of recombinant human interferon alpha 2b in glycoengineeredPichia pastoris:culture medium optimization, high cell density cultivation and biological characterization
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    Journal of Applied Microbiology 2019 126 5
  • Generic biomass estimation methods targeting physiologic process control in induced bacterial cultures
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    Engineering in Life Sciences 2016 16 8
  • Ex situonline monitoring: application, challenges and opportunities for biopharmaceuticals processes
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    Pharmaceutical Bioprocessing 2014 2 3
  • Accelerating bioprocess development by analysis of all available data: A USP case study
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  • Physiological capacities decline during induced bioprocesses leading to substrate accumulation
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    Biotechnology Journal 2017 12 7
  • Comparison of data science workflows for root cause analysis of bioprocesses
    Daniel Borchert, Diego A. Suarez-Zuluaga, Patrick Sagmeister, Yvonne E. Thomassen, Christoph Herwig
    Bioprocess and Biosystems Engineering 2019 42 2
  • Propagation of measurement accuracy to biomass soft-sensor estimation and control quality
    Valentin Steinwandter, Thomas Zahel, Patrick Sagmeister, Christoph Herwig
    Analytical and Bioanalytical Chemistry 2017 409 3
  • Monte Carlo-Based Error Propagation for a More Reliable Regression Analysis across Specific Rates in Bioprocesses
    Julian Kager, Christoph Herwig
    Bioengineering 2021 8 11
  • Industrial Scale Suspension Culture of Living Cells
    Patrick Sagmeister, Mohammadhadi Jazini, Joachim Klein, Christoph Herwig
    2014
  • Bioprocess development workflow: Transferable physiological knowledge instead of technological correlations
    Wieland N. Reichelt, Florian Haas, Patrick Sagmeister, Christoph Herwig
    Biotechnology Progress 2017 33 1
  • Accurate Information from Fermentation Processes – Optimal Rate Calculation by Dynamic Window Adaptation
    Thomas Zahel, Patrick Sagmeister, Szymon Suchocki, Christoph Herwig
    Chemie Ingenieur Technik 2016 88 6
  • Dynamic Experiments for Bioprocess Parameter Optimization with Extreme Halophilic Archaea
    Bettina Lorantfy, Bernhard Seyer, Christoph Herwig
    Bioengineering 2013 1 1
  • Risk assessment and integrated process modeling–an improved QbD approach for the development of the bioprocess control strategy
    Daniel Borchert, Diego A. Suarez-Zuluaga, Yvonne E. Thomassen, Christoph Herwig
    AIMS Bioengineering 2020 7 4
  • Targeted Deletion of Los1 Homologue Affects the Production of a Recombinant Model Protein in Pichia pastoris
    Najmeh Zarei, Hosnieh Ghasemi, Mahsa Nayebhashemi, Mozhgan Zahmatkesh, Monire Jamalkhah, Nafiseh Moeinian, Zahra Mohammadi, Somayeh Enayati, Vahid Khalaj
    Iranian Biomedical Journal 2021 25 4
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PDA Journal of Pharmaceutical Science and Technology: 66 (6)
PDA Journal of Pharmaceutical Science and Technology
Vol. 66, Issue 6
November/December 2012
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Information Processing: Rate-Based Investigation of Cell Physiological Changes along Design Space Development
Patrick Sagmeister, Patrick Wechselberger, Christoph Herwig
PDA Journal of Pharmaceutical Science and Technology Nov 2012, 66 (6) 526-541; DOI: 10.5731/pdajpst.2012.00889

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Information Processing: Rate-Based Investigation of Cell Physiological Changes along Design Space Development
Patrick Sagmeister, Patrick Wechselberger, Christoph Herwig
PDA Journal of Pharmaceutical Science and Technology Nov 2012, 66 (6) 526-541; DOI: 10.5731/pdajpst.2012.00889
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Keywords

  • Quality by Design
  • Process development
  • Process optimization
  • Multivariate data analysis
  • Design of Experiments
  • Design space development
  • Data processing
  • Information processing

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