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Research ArticleResearch

Identification of a Leachable Compound Detrimental to Cell Growth in Single-Use Bioprocess Containers

Matthew Hammond, Heather Nunn, Gary Rogers, Hans Lee, Anatolia-Liliana Marghitoiu, Lourdes Perez, Yasser Nashed-Samuel, Carl Anderson, Michael Vandiver and Sally Kline
PDA Journal of Pharmaceutical Science and Technology March 2013, 67 (2) 123-134; DOI: https://doi.org/10.5731/pdajpst.2013.00905
Matthew Hammond
‡Product Attribute Sciences;
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  • For correspondence: mhammond@amgen.com
Heather Nunn
§Cell Sciences & Technology, Amgen Inc., Seattle, WA; and
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Gary Rogers
‡Product Attribute Sciences;
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Hans Lee
|Product Contact Assessment;
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Anatolia-Liliana Marghitoiu
|Product Contact Assessment;
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Lourdes Perez
|Product Contact Assessment;
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Yasser Nashed-Samuel
|Product Contact Assessment;
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Carl Anderson
∧Pilot Plant Operations, Amgen Inc., Bothell, WA
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Michael Vandiver
∧Pilot Plant Operations, Amgen Inc., Bothell, WA
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Sally Kline
†Materials Science, Amgen Inc., Thousand Oaks, CA;
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PDA Journal of Pharmaceutical Science and Technology: 67 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 67, Issue 2
March/April 2013
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Identification of a Leachable Compound Detrimental to Cell Growth in Single-Use Bioprocess Containers
Matthew Hammond, Heather Nunn, Gary Rogers, Hans Lee, Anatolia-Liliana Marghitoiu, Lourdes Perez, Yasser Nashed-Samuel, Carl Anderson, Michael Vandiver, Sally Kline
PDA Journal of Pharmaceutical Science and Technology Mar 2013, 67 (2) 123-134; DOI: 10.5731/pdajpst.2013.00905

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Identification of a Leachable Compound Detrimental to Cell Growth in Single-Use Bioprocess Containers
Matthew Hammond, Heather Nunn, Gary Rogers, Hans Lee, Anatolia-Liliana Marghitoiu, Lourdes Perez, Yasser Nashed-Samuel, Carl Anderson, Michael Vandiver, Sally Kline
PDA Journal of Pharmaceutical Science and Technology Mar 2013, 67 (2) 123-134; DOI: 10.5731/pdajpst.2013.00905
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Keywords

  • Bioprocess container
  • Extractables
  • Leachables
  • Cell growth
  • Polyethylene
  • Irgafos

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