Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
PDA Journal of Pharmaceutical Science and Technology
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
PDA Journal of Pharmaceutical Science and Technology

Advanced Search

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • Follow pda on Twitter
  • Visit PDA on LinkedIn
  • Visit pda on Facebook
Research ArticleTechnology/Application

A Method Utilizing Ultra-High Performance Liquid Chromatography with Ultraviolet and Mass Spectrometric Detection for the Analysis of Material Extracts Produced during a Controlled Extraction Study

Steven A. Zdravkovic, Matthew D. Bruss, Robert F. Piccoli and Derek M. Wood
PDA Journal of Pharmaceutical Science and Technology September 2014, 68 (5) 504-526; DOI: https://doi.org/10.5731/pdajpst.2014.00992
Steven A. Zdravkovic
cGMP Laboratory, Pharmaceutical Product Development, Inc. (PPD), 8551 Research Way, Suite 90, Middleton, WI 53562, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: Steve.Zdravkovic@ppdi.com
Matthew D. Bruss
cGMP Laboratory, Pharmaceutical Product Development, Inc. (PPD), 8551 Research Way, Suite 90, Middleton, WI 53562, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert F. Piccoli
cGMP Laboratory, Pharmaceutical Product Development, Inc. (PPD), 8551 Research Way, Suite 90, Middleton, WI 53562, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Derek M. Wood
cGMP Laboratory, Pharmaceutical Product Development, Inc. (PPD), 8551 Research Way, Suite 90, Middleton, WI 53562, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

Article Information

vol. 68 no. 5 504-526
DOI 
https://doi.org/10.5731/pdajpst.2014.00992
PubMed 
25336421

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online October 21, 2014.

Copyright & Usage 
© PDA, Inc. 2014

Author Information

  1. Steven A. Zdravkovic*,
  2. Matthew D. Bruss,
  3. Robert F. Piccoli and
  4. Derek M. Wood
  1. cGMP Laboratory, Pharmaceutical Product Development, Inc. (PPD), 8551 Research Way, Suite 90, Middleton, WI 53562, United States
  1. ↵* Corresponding author: Steve Zdravkovic, PPD, 8551 Research Way, Suite 90, Middleton, WI 53562. Telephone: (608) 203-4364; e-mail: Steve.Zdravkovic{at}ppdi.com
View Full Text

Cited By...

  • 7 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Identification, analysis and safety assessment of leachables and extractables
    Dennis Jenke
    TrAC Trends in Analytical Chemistry 2018 101
  • Leachables from plastic materials in contact with drugs. State of the art and review of current analytical approaches
    Luis Cuadros-Rodríguez, Marta Lazúen-Muros, Cristina Ruiz-Samblás, Natalia Navas-Iglesias
    International Journal of Pharmaceutics 2020 583
  • Establishment of a reference standard database for use in the qualitative and semi-quantitative analysis of pharmaceutical contact materials within an extractables survey by GC–MS
    Steven A. Zdravkovic, Cindy T. Duong, Ashley A. Hellenbrand, Steven R. Duff, Alyssa L. Dreger
    Journal of Pharmaceutical and Biomedical Analysis 2018 151
  • Solid phase extraction in tandem with GC/MS for the determination of semi-volatile organic substances extracted from pharmaceutical packaging/delivery systems via aqueous solvent systems
    Steven A. Zdravkovic
    Journal of Pharmaceutical and Biomedical Analysis 2015 112
  • Identification of UV-absorbing extractables from rubber closures used in containers of injectable powder and safety assessment of leachables in the drug
    Yulei Wei, Ying Wu, Tingli Zhu, Zhiyan Li, Yilan Zhang
    Journal of Pharmaceutical and Biomedical Analysis 2017 138
  • Chemical Characterization and Non-targeted Analysis of Medical Device Extracts: A Review of Current Approaches, Gaps, and Emerging Practices
    Eric M. Sussman, Berk Oktem, Irada S. Isayeva, Jinrong Liu, Samanthi Wickramasekara, Vaishnavi Chandrasekar, Keaton Nahan, Hainsworth Y. Shin, Jiwen Zheng
    ACS Biomaterials Science & Engineering 2022 8 3
  • Investigation of Drug-Packaging Interactions with Mass Spectroscopy Detectors: A Meta-Synthesis of the Literature
    Camille Fauchere, Markoulina Berger-Gryllaki, Farshid Sadeghipour
    Pharmaceutical Technology in Hospital Pharmacy 2019 4 1
PreviousNext
Back to top

In This Issue

PDA Journal of Pharmaceutical Science and Technology: 68 (5)
PDA Journal of Pharmaceutical Science and Technology
Vol. 68, Issue 5
September/October 2014
  • Table of Contents
  • Index by Author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
A Method Utilizing Ultra-High Performance Liquid Chromatography with Ultraviolet and Mass Spectrometric Detection for the Analysis of Material Extracts Produced during a Controlled Extraction Study
(Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology
(Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
18 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
A Method Utilizing Ultra-High Performance Liquid Chromatography with Ultraviolet and Mass Spectrometric Detection for the Analysis of Material Extracts Produced during a Controlled Extraction Study
Steven A. Zdravkovic, Matthew D. Bruss, Robert F. Piccoli, Derek M. Wood
PDA Journal of Pharmaceutical Science and Technology Sep 2014, 68 (5) 504-526; DOI: 10.5731/pdajpst.2014.00992

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
A Method Utilizing Ultra-High Performance Liquid Chromatography with Ultraviolet and Mass Spectrometric Detection for the Analysis of Material Extracts Produced during a Controlled Extraction Study
Steven A. Zdravkovic, Matthew D. Bruss, Robert F. Piccoli, Derek M. Wood
PDA Journal of Pharmaceutical Science and Technology Sep 2014, 68 (5) 504-526; DOI: 10.5731/pdajpst.2014.00992
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Experimental
    • Results and Discussion
    • Case Studies
    • Conclusions
    • Conflict of Interest Declaration
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • The Implications of Chromatographically Screening Medical Products for Organic Leachables Down to the Analytical Evaluation Threshold Adjusted for Response Factor Variation
  • Google Scholar

More in this TOC Section

  • Set-up of a Contamination Control Strategy using the Hazard Analysis Critical Control Point (HACCP) methodology
  • Evaluation of the Design, Development, and Performance of a Mass-Flow Based, Open-Source Buffer Manufacturing System
  • Development and Qualification of Visible Particle Load Analysis Methods for Injectable Drug Product Primary Packaging Components
Show more Technology/Application

Similar Articles

Keywords

  • extractables
  • leachables
  • UHPLC/UV/MS
  • LC/MS
  • controlled extraction study

>

Readers

  • About
  • Table of Content Alerts/Other Alerts
  • Subscriptions
  • Terms of Use
  • Contact Editors

Author/Reviewer Information

  • Author Resources
  • Submit Manuscript
  • Reviewers
  • Contact Editors

Parenteral Drug Association, Inc.

  • About
  • Advertising/Sponsorships
  • Events
  • PDA Bookstore
  • Press Releases

© 2023 PDA Journal of Pharmaceutical Science and Technology ISSN: 1079-7440

Powered by HighWire