A Method Utilizing Ultra-High Performance Liquid Chromatography with Ultraviolet and Mass Spectrometric Detection for the Analysis of Material Extracts Produced during a Controlled Extraction Study

Steven A. Zdravkovic; Matthew D. Bruss; Robert F. Piccoli; Derek M. Wood

doi:10.5731/pdajpst.2014.00992

Research ArticleTechnology/Application

A Method Utilizing Ultra-High Performance Liquid Chromatography with Ultraviolet and Mass Spectrometric Detection for the Analysis of Material Extracts Produced during a Controlled Extraction Study

Steven A. Zdravkovic, Matthew D. Bruss, Robert F. Piccoli and Derek M. Wood

PDA Journal of Pharmaceutical Science and Technology September 2014, 68 (5) 504-526; DOI: https://doi.org/10.5731/pdajpst.2014.00992

Steven A. Zdravkovic

cGMP Laboratory, Pharmaceutical Product Development, Inc. (PPD), 8551 Research Way, Suite 90, Middleton, WI 53562, United States

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For correspondence: Steve.Zdravkovic@ppdi.com

Matthew D. Bruss

cGMP Laboratory, Pharmaceutical Product Development, Inc. (PPD), 8551 Research Way, Suite 90, Middleton, WI 53562, United States

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Robert F. Piccoli

cGMP Laboratory, Pharmaceutical Product Development, Inc. (PPD), 8551 Research Way, Suite 90, Middleton, WI 53562, United States

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Derek M. Wood

cGMP Laboratory, Pharmaceutical Product Development, Inc. (PPD), 8551 Research Way, Suite 90, Middleton, WI 53562, United States

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vol. 68 no. 5 504-526

DOI

https://doi.org/10.5731/pdajpst.2014.00992

PubMed

25336421

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online October 21, 2014.

Author Information

Steven A. Zdravkovic*,
Matthew D. Bruss,
Robert F. Piccoli and
Derek M. Wood

cGMP Laboratory, Pharmaceutical Product Development, Inc. (PPD), 8551 Research Way, Suite 90, Middleton, WI 53562, United States

↵* Corresponding author: Steve Zdravkovic, PPD, 8551 Research Way, Suite 90, Middleton, WI 53562. Telephone: (608) 203-4364; e-mail: Steve.Zdravkovic{at}ppdi.com

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A Method Utilizing Ultra-High Performance Liquid Chromatography with Ultraviolet and Mass Spectrometric Detection for the Analysis of Material Extracts Produced during a Controlled Extraction Study

Steven A. Zdravkovic, Matthew D. Bruss, Robert F. Piccoli, Derek M. Wood

PDA Journal of Pharmaceutical Science and Technology Sep 2014, 68 (5) 504-526; DOI: 10.5731/pdajpst.2014.00992

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A Method Utilizing Ultra-High Performance Liquid Chromatography with Ultraviolet and Mass Spectrometric Detection for the Analysis of Material Extracts Produced during a Controlled Extraction Study

Steven A. Zdravkovic, Matthew D. Bruss, Robert F. Piccoli, Derek M. Wood

PDA Journal of Pharmaceutical Science and Technology Sep 2014, 68 (5) 504-526; DOI: 10.5731/pdajpst.2014.00992

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Keywords

extractables
leachables
UHPLC/UV/MS
LC/MS
controlled extraction study

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A Method Utilizing Ultra-High Performance Liquid Chromatography with Ultraviolet and Mass Spectrometric Detection for the Analysis of Material Extracts Produced during a Controlled Extraction Study

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