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Reciprocal Translocation Observed in End-of-Production Cells of a Commercial CHO-Based Process

Yolande Rouiller, Beate Kleuser, Emiliano Toso, Wolf Palinksy, Mara Rossi, Paola Rossatto, Davide Barberio and Hervé Broly
PDA Journal of Pharmaceutical Science and Technology July 2015, 69 (4) 540-552; DOI: https://doi.org/10.5731/pdajpst.2015.01063
Yolande Rouiller
1Merck Serono SA, Corsier-sur-Vevey, Biotech Process Sciences, Fenil-sur-Corsier, Switzerland;
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  • For correspondence: yolande.rouiller@merckgroup.com
Beate Kleuser
1Merck Serono SA, Corsier-sur-Vevey, Biotech Process Sciences, Fenil-sur-Corsier, Switzerland;
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Emiliano Toso
2Istituto Ricerche Biomediche Antoine Marxer RBM, Merck Group, MS-TDS-B2 Department, Colleretto Giacosa, Italy;
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Wolf Palinksy
3Merck Serono SA, Global Research and Development, Coinsins, Switzerland;
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Mara Rossi
4Merck Serono S.p.A., MS-TDA-P Department, Guidonia Montecelio, Italy; and
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Paola Rossatto
2Istituto Ricerche Biomediche Antoine Marxer RBM, Merck Group, MS-TDS-B2 Department, Colleretto Giacosa, Italy;
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Davide Barberio
5Bioclarma srl, Torino, Italy
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Hervé Broly
1Merck Serono SA, Corsier-sur-Vevey, Biotech Process Sciences, Fenil-sur-Corsier, Switzerland;
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Article Information

vol. 69 no. 4 540-552
DOI 
https://doi.org/10.5731/pdajpst.2015.01063

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online August 4, 2015.

Copyright & Usage 
© PDA, Inc. 2015

Author Information

  1. Yolande Rouiller1,*,
  2. Beate Kleuser1,
  3. Emiliano Toso2,
  4. Wolf Palinksy3,
  5. Mara Rossi4,
  6. Paola Rossatto2,
  7. Davide Barberio5 and
  8. Hervé Broly1
  1. 1Merck Serono SA, Corsier-sur-Vevey, Biotech Process Sciences, Fenil-sur-Corsier, Switzerland;
  2. 2Istituto Ricerche Biomediche Antoine Marxer RBM, Merck Group, MS-TDS-B2 Department, Colleretto Giacosa, Italy;
  3. 3Merck Serono SA, Global Research and Development, Coinsins, Switzerland;
  4. 4Merck Serono S.p.A., MS-TDA-P Department, Guidonia Montecelio, Italy; and
  5. 5Bioclarma srl, Torino, Italy
  1. ↵*Corresponding author: Yolande Rouiller, Merck Serono SA, Corsier-sur-Vevey, Biotech Process Sciences, ZI B, CH-1809 Fenil-sur-Corsier, Switzerland; telephone: +41 21 923 2207; fax: +41 21 923 2013; e-mail: yolande.rouiller@merckgroup.com
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PDA Journal of Pharmaceutical Science and Technology: 69 (4)
PDA Journal of Pharmaceutical Science and Technology
Vol. 69, Issue 4
July/August 2015
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Reciprocal Translocation Observed in End-of-Production Cells of a Commercial CHO-Based Process
Yolande Rouiller, Beate Kleuser, Emiliano Toso, Wolf Palinksy, Mara Rossi, Paola Rossatto, Davide Barberio, Hervé Broly
PDA Journal of Pharmaceutical Science and Technology Jul 2015, 69 (4) 540-552; DOI: 10.5731/pdajpst.2015.01063
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Keywords

  • Commercial process
  • Recombinant protein
  • CHO cells
  • Validation
  • Cell banks
  • Genetics

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Reciprocal Translocation Observed in End-of-Production Cells of a Commercial CHO-Based Process
Yolande Rouiller, Beate Kleuser, Emiliano Toso, Wolf Palinksy, Mara Rossi, Paola Rossatto, Davide Barberio, Hervé Broly
PDA Journal of Pharmaceutical Science and Technology Jul 2015, 69 (4) 540-552; DOI: 10.5731/pdajpst.2015.01063

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