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Research ArticleResearch

Low Leachable Container System Consisting of a Polymer-Based Syringe with Chlorinated Isoprene Isobutene Rubber Plunger Stopper

Hideaki Kiminami, Katsuyuki Takeuchi, Koji Nakamura, Yoshihiko Abe, Philippe Lauwers, William Dierick, Keisuke Yoshino and Shigeru Suzuki
PDA Journal of Pharmaceutical Science and Technology November 2015, 69 (6) 713-724; DOI: https://doi.org/10.5731/pdajpst.2015.01080
Hideaki Kiminami
1Terumo Corporation, R&D Center, Nakai-machi, Ashigarakami-gun, Kanagawa, Japan; and
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  • For correspondence: Hideaki_Kiminami@terumo.co.jp
Katsuyuki Takeuchi
1Terumo Corporation, R&D Center, Nakai-machi, Ashigarakami-gun, Kanagawa, Japan; and
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Koji Nakamura
1Terumo Corporation, R&D Center, Nakai-machi, Ashigarakami-gun, Kanagawa, Japan; and
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Yoshihiko Abe
1Terumo Corporation, R&D Center, Nakai-machi, Ashigarakami-gun, Kanagawa, Japan; and
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Philippe Lauwers
2Terumo Europe NV, Interleuvenlaan 40, 3001 Leuven, Belgium
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William Dierick
2Terumo Europe NV, Interleuvenlaan 40, 3001 Leuven, Belgium
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Keisuke Yoshino
1Terumo Corporation, R&D Center, Nakai-machi, Ashigarakami-gun, Kanagawa, Japan; and
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Shigeru Suzuki
1Terumo Corporation, R&D Center, Nakai-machi, Ashigarakami-gun, Kanagawa, Japan; and
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Article Information

vol. 69 no. 6 713-724
DOI 
https://doi.org/10.5731/pdajpst.2015.01080
PubMed 
26659102

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online December 10, 2015.

Copyright & Usage 
© PDA, Inc. 2015

Author Information

  1. Hideaki Kiminami1,*,
  2. Katsuyuki Takeuchi1,
  3. Koji Nakamura1,
  4. Yoshihiko Abe1,
  5. Philippe Lauwers2,
  6. William Dierick2,
  7. Keisuke Yoshino1 and
  8. Shigeru Suzuki1
  1. 1Terumo Corporation, R&D Center, Nakai-machi, Ashigarakami-gun, Kanagawa, Japan; and
  2. 2Terumo Europe NV, Interleuvenlaan 40, 3001 Leuven, Belgium
  1. ↵*Corresponding Author: Hideaki Kiminami, 1500 Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa 259-0151, Japan. Telephone: +81-465-81-4195; Fax: +81-465-80-0590; e-mail: Hideaki_Kiminami{at}terumo.co.jp
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PDA Journal of Pharmaceutical Science and Technology: 69 (6)
PDA Journal of Pharmaceutical Science and Technology
Vol. 69, Issue 6
November/December 2015
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Low Leachable Container System Consisting of a Polymer-Based Syringe with Chlorinated Isoprene Isobutene Rubber Plunger Stopper
Hideaki Kiminami, Katsuyuki Takeuchi, Koji Nakamura, Yoshihiko Abe, Philippe Lauwers, William Dierick, Keisuke Yoshino, Shigeru Suzuki
PDA Journal of Pharmaceutical Science and Technology Nov 2015, 69 (6) 713-724; DOI: 10.5731/pdajpst.2015.01080

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Low Leachable Container System Consisting of a Polymer-Based Syringe with Chlorinated Isoprene Isobutene Rubber Plunger Stopper
Hideaki Kiminami, Katsuyuki Takeuchi, Koji Nakamura, Yoshihiko Abe, Philippe Lauwers, William Dierick, Keisuke Yoshino, Shigeru Suzuki
PDA Journal of Pharmaceutical Science and Technology Nov 2015, 69 (6) 713-724; DOI: 10.5731/pdajpst.2015.01080
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    • 1. Introduction
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Keywords

  • Cyclo olefin polymer
  • Chlorinated isoprene isobutene rubber
  • Butyl rubber
  • Label
  • Label printing
  • Adhesive
  • Secondary packaging
  • Extractable
  • leachable
  • stability
  • Prefilled
  • prefillable syringe

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