Hydrolysis of Polysorbate 20 and 80 by a Range of Carboxylester Hydrolases

Andrew C. McShan; Pervina Kei; Junyan A. Ji; Daniel C. Kim; Y. John Wang

doi:10.5731/pdajpst.2015.005942

Research ArticleResearch

Hydrolysis of Polysorbate 20 and 80 by a Range of Carboxylester Hydrolases

Andrew C. McShan, Pervina Kei, Junyan A. Ji, Daniel C. Kim and Y. John Wang

PDA Journal of Pharmaceutical Science and Technology July 2016, 70 (4) 332-345; DOI: https://doi.org/10.5731/pdajpst.2015.005942

Andrew C. McShan

1Department of Late Stage Pharmaceutical Development, Genentech, Inc., South San Francisco, CA 94080;

3Department of Molecular Biosciences, University of Kansas, Lawrence, KS;

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Pervina Kei

2Department of Early Stage Pharmaceutical Development, Genentech, Inc., South San Francisco, CA 94080;

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Junyan A. Ji

1Department of Late Stage Pharmaceutical Development, Genentech, Inc., South San Francisco, CA 94080;

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Daniel C. Kim

1Department of Late Stage Pharmaceutical Development, Genentech, Inc., South San Francisco, CA 94080;

4Ralph N. Adams Institute for Bioanalytical Chemistry, University of Kansas, Lawrence, KS

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Y. John Wang

1Department of Late Stage Pharmaceutical Development, Genentech, Inc., South San Francisco, CA 94080;

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For correspondence: wang.john@gene.com

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Article Information

vol. 70 no. 4 332-345

DOI

https://doi.org/10.5731/pdajpst.2015.005942

PubMed

27020650

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online July 18, 2016.

Article Versions

previous version (March 28, 2016 - 17:56).
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Author Information

Andrew C. McShan1,3,
Pervina Kei2,
Junyan A. Ji1,
Daniel C. Kim1,4 and
Y. John Wang1,5

¹Department of Late Stage Pharmaceutical Development, Genentech, Inc., South San Francisco, CA 94080;
²Department of Early Stage Pharmaceutical Development, Genentech, Inc., South San Francisco, CA 94080;
³Department of Molecular Biosciences, University of Kansas, Lawrence, KS;
⁴Ralph N. Adams Institute for Bioanalytical Chemistry, University of Kansas, Lawrence, KS

↵5Corresponding Author: wang.john{at}gene.com

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Hydrolysis of Polysorbate 20 and 80 by a Range of Carboxylester Hydrolases

Andrew C. McShan, Pervina Kei, Junyan A. Ji, Daniel C. Kim, Y. John Wang

PDA Journal of Pharmaceutical Science and Technology Jul 2016, 70 (4) 332-345; DOI: 10.5731/pdajpst.2015.005942

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Hydrolysis of Polysorbate 20 and 80 by a Range of Carboxylester Hydrolases

Andrew C. McShan, Pervina Kei, Junyan A. Ji, Daniel C. Kim, Y. John Wang

PDA Journal of Pharmaceutical Science and Technology Jul 2016, 70 (4) 332-345; DOI: 10.5731/pdajpst.2015.005942

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