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Research ArticleResearch

Qualification of a Quantitative Method for Monitoring Aspartate Isomerization of a Monoclonal Antibody by Focused Peptide Mapping

Mingyan Cao, Wenjun (David) Mo, Anthony Shannon, Ziping Wei, Michael Washabaugh and Patricia Cash
PDA Journal of Pharmaceutical Science and Technology November 2016, 70 (6) 490-507; DOI: https://doi.org/10.5731/pdajpst.2015.006239
Mingyan Cao
Analytical Biotechnology Department, MedImmune Inc, Gaithersburg, MD
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Wenjun (David) Mo
Analytical Biotechnology Department, MedImmune Inc, Gaithersburg, MD
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Anthony Shannon
Analytical Biotechnology Department, MedImmune Inc, Gaithersburg, MD
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Ziping Wei
Analytical Biotechnology Department, MedImmune Inc, Gaithersburg, MD
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Michael Washabaugh
Analytical Biotechnology Department, MedImmune Inc, Gaithersburg, MD
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  • For correspondence: michael.washabaugh@theraproteins.com Patriciacash8@gmail.com
Patricia Cash
Analytical Biotechnology Department, MedImmune Inc, Gaithersburg, MD
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  • For correspondence: michael.washabaugh@theraproteins.com Patriciacash8@gmail.com
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Article Information

vol. 70 no. 6 490-507
DOI 
https://doi.org/10.5731/pdajpst.2015.006239
PubMed 
27091886

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online December 13, 2016.

Article Versions

  • previous version (April 18, 2016 - 18:05).
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Copyright & Usage 
© PDA, Inc. 2016

Author Information

  1. Mingyan Cao,
  2. Wenjun (David) Mo,
  3. Anthony Shannon,
  4. Ziping Wei,
  5. Michael Washabaugh* and
  6. Patricia Cash*
  1. Analytical Biotechnology Department, MedImmune Inc, Gaithersburg, MD
  1. ↵* Corresponding Authors: Michael Washabaugh, Current affiliation: TheraProteins Inc., 3440 S. Dearborn St. Suite 300, Chicago, IL 60616; e-mail: michael.washabaugh{at}theraproteins.com; Patricia Cash; e-mail: Patriciacash8{at}gmail.com
  • Current affiliation of Wenjun (David) Mo: Bio-Thera Solutions, Ltd, Guangzhou, China; Current affiliation of Ziping Wei: Novavax Inc, 9920 Belward Campus Drive, Rockville, MD 20850.

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PDA Journal of Pharmaceutical Science and Technology: 70 (6)
PDA Journal of Pharmaceutical Science and Technology
Vol. 70, Issue 6
November/December 2016
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Qualification of a Quantitative Method for Monitoring Aspartate Isomerization of a Monoclonal Antibody by Focused Peptide Mapping
Mingyan Cao, Wenjun (David) Mo, Anthony Shannon, Ziping Wei, Michael Washabaugh, Patricia Cash
PDA Journal of Pharmaceutical Science and Technology Nov 2016, 70 (6) 490-507; DOI: 10.5731/pdajpst.2015.006239

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Qualification of a Quantitative Method for Monitoring Aspartate Isomerization of a Monoclonal Antibody by Focused Peptide Mapping
Mingyan Cao, Wenjun (David) Mo, Anthony Shannon, Ziping Wei, Michael Washabaugh, Patricia Cash
PDA Journal of Pharmaceutical Science and Technology Nov 2016, 70 (6) 490-507; DOI: 10.5731/pdajpst.2015.006239
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Keywords

  • Monoclonal antibody (mAb)
  • Complementarity-determining regions (CDRs)
  • Aspartic acid Isomerization
  • Focused peptide mapping
  • Method qualification

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