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Research ArticleResearch

Kinetic Modeling of the Release of Ethylene Oxide from Sterilized Plastic Containers and its Interaction with Monoclonal Antibodies

Bryan Lei Yu, Jun Han, Matthew Hammond, Xuemei Wang, Qingchun Zhang, Andrew Clausen, Ronald Forster and Mingda Eu
PDA Journal of Pharmaceutical Science and Technology January 2017, 71 (1) 11-19; DOI: https://doi.org/10.5731/pdajpst.2015.005819
Bryan Lei Yu
4Device Technologies, Process Development, Amgen Inc., Thousand Oaks, CA
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  • For correspondence: Bryan.yu@amgen.com
Jun Han
3Attribute Sciences, Process Development, Amgen Inc., Thousand Oaks, CA;
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Matthew Hammond
3Attribute Sciences, Process Development, Amgen Inc., Thousand Oaks, CA;
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Xuemei Wang
3Attribute Sciences, Process Development, Amgen Inc., Thousand Oaks, CA;
1Current affiliation: Kythera Biopharmaceuticals, Westlake, CA;
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Qingchun Zhang
3Attribute Sciences, Process Development, Amgen Inc., Thousand Oaks, CA;
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Andrew Clausen
3Attribute Sciences, Process Development, Amgen Inc., Thousand Oaks, CA;
2Current affiliation: Snapdragon Chemistry, Cambridge, MA;
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Ronald Forster
4Device Technologies, Process Development, Amgen Inc., Thousand Oaks, CA
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Mingda Eu
4Device Technologies, Process Development, Amgen Inc., Thousand Oaks, CA
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Article Information

vol. 71 no. 1 11-19
DOI 
https://doi.org/10.5731/pdajpst.2015.005819
PubMed 
28174258

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online February 6, 2017.

Article Versions

  • previous version (December 14, 2016 - 05:03).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© PDA, Inc. 2017

Author Information

  1. Bryan Lei Yu4,*,
  2. Jun Han3,
  3. Matthew Hammond3,
  4. Xuemei Wang3,1,
  5. Qingchun Zhang3,
  6. Andrew Clausen3,2,
  7. Ronald Forster4 and
  8. Mingda Eu4
  1. 1Current affiliation: Kythera Biopharmaceuticals, Westlake, CA;
  2. 2Current affiliation: Snapdragon Chemistry, Cambridge, MA;
  3. 3Attribute Sciences, Process Development, Amgen Inc., Thousand Oaks, CA;
  4. 4Device Technologies, Process Development, Amgen Inc., Thousand Oaks, CA
  1. ↵* Corresponding Author: Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320; Bryan.yu@amgen.com
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PDA Journal of Pharmaceutical Science and Technology: 71 (1)
PDA Journal of Pharmaceutical Science and Technology
Vol. 71, Issue 1
January/February 2017
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Kinetic Modeling of the Release of Ethylene Oxide from Sterilized Plastic Containers and its Interaction with Monoclonal Antibodies
Bryan Lei Yu, Jun Han, Matthew Hammond, Xuemei Wang, Qingchun Zhang, Andrew Clausen, Ronald Forster, Mingda Eu
PDA Journal of Pharmaceutical Science and Technology Jan 2017, 71 (1) 11-19; DOI: 10.5731/pdajpst.2015.005819
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Keywords

  • ethylene oxide
  • plastic container
  • Headspace–gas chromatography
  • Mass spectrometry
  • Antibody
  • Chemical modification

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Kinetic Modeling of the Release of Ethylene Oxide from Sterilized Plastic Containers and its Interaction with Monoclonal Antibodies
Bryan Lei Yu, Jun Han, Matthew Hammond, Xuemei Wang, Qingchun Zhang, Andrew Clausen, Ronald Forster, Mingda Eu
PDA Journal of Pharmaceutical Science and Technology Jan 2017, 71 (1) 11-19; DOI: 10.5731/pdajpst.2015.005819

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