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History
- Published online February 6, 2017.
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- previous version (August 11, 2016 - 05:59).
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© PDA, Inc. 2017
Author Information
- Tobias Werk1,2,3,*,
- Hanns-Christian Mahler4,
- Imke Sonja Ludwig2,
- Joerg Luemkemann2,
- Joerg Huwyler1 and
- Mathias Hafner3
- 1Pharmaceutical Technology, University of Basel, Basel (Switzerland);
- 2Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel (Switzerland);
- 3Institute for Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, Mannheim (Germany); and
- 4Lonza AG, Drug Product Services, Basel (Switzerland)
- ↵* Corresponding Author: Tobias Werk, e-mail: tobias.werk{at}roche.com
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- Article
- Abstract
- Introduction
- Improved Efficacy Using Drug/Drug Fixed-Dose Combinations (FDCs)
- Improved Stability, Solubility, and Applicability
- Special Drug Delivery Applications
- Challenges and Aim of This Study
- Materials and Methods
- Results and Discussion
- Mixing: Impact of Solution Viscosity/Density
- Mixing: Impact of Head Chamber Fill Volume
- Mixing: Impact of Ejection Angle
- Mixing: Impact of Agitation
- Mixing: Impact of Ejection Speed
- Mixing: Impact of Bypass Design
- Conclusions
- Conflict of Interest Declaration
- Acknowledgments
- References
- Figures & Data
- References
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