Research ArticleResearch
A Method To Determine the Kinetics of Solute Mixing in Liquid/Liquid Formulation Dual-Chamber Syringes
Tobias Werk, Hanns-Christian Mahler, Imke Sonja Ludwig, Joerg Luemkemann, Joerg Huwyler and Mathias Hafner
PDA Journal of Pharmaceutical Science and Technology January 2017, 71 (1) 2-10; DOI: https://doi.org/10.5731/pdajpst.2016.006601
Tobias Werk
1Pharmaceutical Technology, University of Basel, Basel (Switzerland);
2Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel (Switzerland);
3Institute for Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, Mannheim (Germany); and
Hanns-Christian Mahler
4Lonza AG, Drug Product Services, Basel (Switzerland)
Imke Sonja Ludwig
2Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel (Switzerland);
Joerg Luemkemann
2Pharmaceutical Development & Supplies, F. Hoffmann-La Roche Ltd., Basel (Switzerland);
Joerg Huwyler
1Pharmaceutical Technology, University of Basel, Basel (Switzerland);
Mathias Hafner
3Institute for Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, Mannheim (Germany); and

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- Michaels T. M. Jr..
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- Werk T.,
- Luemkemann J.,
- Mahler H. C.
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- Kararli T. T.,
- Sedo K.,
- Bosshart J.
- 5.↵
- Chu E.,
- DeVita V.
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- Lipinski C. A.,
- Lombardo F.,
- Dominy B. W.,
- Feeney P. J.
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- Frost G. I.
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- Allmendinger A.,
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In This Issue
PDA Journal of Pharmaceutical Science and Technology
Vol. 71, Issue 1
January/February 2017
A Method To Determine the Kinetics of Solute Mixing in Liquid/Liquid Formulation Dual-Chamber Syringes
Tobias Werk, Hanns-Christian Mahler, Imke Sonja Ludwig, Joerg Luemkemann, Joerg Huwyler, Mathias Hafner
PDA Journal of Pharmaceutical Science and Technology Jan 2017, 71 (1) 2-10; DOI: 10.5731/pdajpst.2016.006601
A Method To Determine the Kinetics of Solute Mixing in Liquid/Liquid Formulation Dual-Chamber Syringes
Tobias Werk, Hanns-Christian Mahler, Imke Sonja Ludwig, Joerg Luemkemann, Joerg Huwyler, Mathias Hafner
PDA Journal of Pharmaceutical Science and Technology Jan 2017, 71 (1) 2-10; DOI: 10.5731/pdajpst.2016.006601
Jump to section
- Article
- Abstract
- Introduction
- Improved Efficacy Using Drug/Drug Fixed-Dose Combinations (FDCs)
- Improved Stability, Solubility, and Applicability
- Special Drug Delivery Applications
- Challenges and Aim of This Study
- Materials and Methods
- Results and Discussion
- Mixing: Impact of Solution Viscosity/Density
- Mixing: Impact of Head Chamber Fill Volume
- Mixing: Impact of Ejection Angle
- Mixing: Impact of Agitation
- Mixing: Impact of Ejection Speed
- Mixing: Impact of Bypass Design
- Conclusions
- Conflict of Interest Declaration
- Acknowledgments
- References
- Figures & Data
- References
- Info & Metrics
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