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Research ArticleResearch

Setting Alert and Action Limits in the Presence of Significant Amount of Censoring in Data

Steven J. Novick, Wei Zhao and Harry Yang
PDA Journal of Pharmaceutical Science and Technology January 2017, 71 (1) 20-32; DOI: https://doi.org/10.5731/pdajpst.2016.006684
Steven J. Novick
MedImmune LLC, Gaithersburg, MD
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Wei Zhao
MedImmune LLC, Gaithersburg, MD
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Harry Yang
MedImmune LLC, Gaithersburg, MD
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PDA Journal of Pharmaceutical Science and Technology: 71 (1)
PDA Journal of Pharmaceutical Science and Technology
Vol. 71, Issue 1
January/February 2017
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Setting Alert and Action Limits in the Presence of Significant Amount of Censoring in Data
Steven J. Novick, Wei Zhao, Harry Yang
PDA Journal of Pharmaceutical Science and Technology Jan 2017, 71 (1) 20-32; DOI: 10.5731/pdajpst.2016.006684

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Setting Alert and Action Limits in the Presence of Significant Amount of Censoring in Data
Steven J. Novick, Wei Zhao, Harry Yang
PDA Journal of Pharmaceutical Science and Technology Jan 2017, 71 (1) 20-32; DOI: 10.5731/pdajpst.2016.006684
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  • Article
    • Abstract
    • 1. Introduction
    • 2. Two-variance Component (2VC) Gaussian Model
    • 3. Single-variance Component (1VC) Gaussian Model
    • 4. Example Data Set
    • 5. Simulation
    • 6. Discussion
    • Conflict of Interest Declaration
    • Acknowledgments
    • Appendix A1. STAN Computer Code for 2VC Gaussian Model
    • Appendix A2. STAN Computer Code for 1VC Gaussian Model
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Keywords

  • Control limits
  • Below limit of quantitation
  • Bayesian
  • Tobit likelihood

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