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PDA Journal of Pharmaceutical Science and Technology

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Research ArticleTechnology/Application

Characterizing the Overall Derivatization of Conjugated Oligomeric Proteins

Michaela Wendeler, Wei Zhao, Christopher Thompson, Manuel Baca, Dhanesh Gadre, Xiangyang Wang and Harry Yang
PDA Journal of Pharmaceutical Science and Technology March 2017, 71 (2) 115-126; DOI: https://doi.org/10.5731/pdajpst.2016.006510
Michaela Wendeler
2Department of Purification Process Sciences, and
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Wei Zhao
1Department of Nonclinical Biostatistics,
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Christopher Thompson
2Department of Purification Process Sciences, and
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Manuel Baca
3Department of Antibody Discovery and Protein Engineering, MedImmune, LLC, Gaithersburg, MD, USA
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Dhanesh Gadre
2Department of Purification Process Sciences, and
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Xiangyang Wang
2Department of Purification Process Sciences, and
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Harry Yang
1Department of Nonclinical Biostatistics,
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  • For correspondence: YangH@MedImmune.com
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Article Information

vol. 71 no. 2 115-126
DOI 
https://doi.org/10.5731/pdajpst.2016.006510
PubMed 
28289128

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online April 10, 2017.

Article Versions

  • previous version (March 13, 2017 - 18:53).
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Copyright & Usage 
© PDA, Inc. 2017

Author Information

  1. Michaela Wendeler2,¶,
  2. Wei Zhao1,¶,
  3. Christopher Thompson2,
  4. Manuel Baca3,
  5. Dhanesh Gadre2,
  6. Xiangyang Wang2 and
  7. Harry Yang1,*
  1. 1Department of Nonclinical Biostatistics,
  2. 2Department of Purification Process Sciences, and
  3. 3Department of Antibody Discovery and Protein Engineering, MedImmune, LLC, Gaithersburg, MD, USA
  1. ↵* Corresponding Author: Harry Yang; MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878 USA. Telephone: +1 301 398 4405; e-mail: YangH{at}MedImmune.com
  1. ↵¶ Both authors contributed equally.

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PDA Journal of Pharmaceutical Science and Technology: 71 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 71, Issue 2
March/April 2017
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Characterizing the Overall Derivatization of Conjugated Oligomeric Proteins
Michaela Wendeler, Wei Zhao, Christopher Thompson, Manuel Baca, Dhanesh Gadre, Xiangyang Wang, Harry Yang
PDA Journal of Pharmaceutical Science and Technology Mar 2017, 71 (2) 115-126; DOI: 10.5731/pdajpst.2016.006510

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Characterizing the Overall Derivatization of Conjugated Oligomeric Proteins
Michaela Wendeler, Wei Zhao, Christopher Thompson, Manuel Baca, Dhanesh Gadre, Xiangyang Wang, Harry Yang
PDA Journal of Pharmaceutical Science and Technology Mar 2017, 71 (2) 115-126; DOI: 10.5731/pdajpst.2016.006510
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Keywords

  • Bioconjugation
  • Oligomeric protein
  • PEGylation
  • Multinomial distribution

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