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Research ArticleResearch

A Bayesian Approach to Determination of F, D, and Z Values Used in Steam Sterilization Validation

Paul Faya, James D. Stamey and John W. Seaman
PDA Journal of Pharmaceutical Science and Technology March 2017, 71 (2) 88-98; DOI: https://doi.org/10.5731/pdajpst.2016.006981
Paul Faya
1Allergan Inc., Waco, TX, ; and
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  • For correspondence: psfaya@gmail.com psfaya@gmail.com
James D. Stamey
2Department of Statistical Science, Baylor University, Waco, TX, USA
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John W. Seaman Jr.
2Department of Statistical Science, Baylor University, Waco, TX, USA
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  • Article
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References

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    1. Holcomb R. G.,
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PDA Journal of Pharmaceutical Science and Technology: 71 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 71, Issue 2
March/April 2017
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A Bayesian Approach to Determination of F, D, and Z Values Used in Steam Sterilization Validation
Paul Faya, James D. Stamey, John W. Seaman
PDA Journal of Pharmaceutical Science and Technology Mar 2017, 71 (2) 88-98; DOI: 10.5731/pdajpst.2016.006981

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A Bayesian Approach to Determination of F, D, and Z Values Used in Steam Sterilization Validation
Paul Faya, James D. Stamey, John W. Seaman
PDA Journal of Pharmaceutical Science and Technology Mar 2017, 71 (2) 88-98; DOI: 10.5731/pdajpst.2016.006981
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  • Article
    • Abstract
    • 1. Introduction
    • 2. Theoretical Background
    • 3. Bayesian Estimation
    • 4. Estimation of Resistance Parameters
    • 5. The Risk of Non-sterility
    • 6. Example
    • 7. Discussion
    • Conflict of Interest Declaration
    • Acknowledgements
    • References
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Keywords

  • Sterilization validation
  • Bayesian
  • Moist heat
  • steam
  • Sterility assurance

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