Holistic Considerations in Optimizing a Sterile Product Package to Ensure Container Closure Integrity

Fran L. Degrazio

doi:10.5731/pdajpst.2017.007658

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Holistic Considerations in Optimizing a Sterile Product Package to Ensure Container Closure Integrity

Fran L. Degrazio

PDA Journal of Pharmaceutical Science and Technology January 2018, 72 (1) 15-34; DOI: https://doi.org/10.5731/pdajpst.2017.007658

Fran L. Degrazio

West Pharmaceutical Services, Inc., 530 Herman O. West Drive, Exton, PA 19341

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For correspondence: fran.degrazio@westpharma.com

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vol. 72 no. 1 15-34

DOI

https://doi.org/10.5731/pdajpst.2017.007658

PubMed

29030527

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online January 30, 2018.

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previous version (October 12, 2017 - 19:14).
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Fran L. Degrazio*

West Pharmaceutical Services, Inc., 530 Herman O. West Drive, Exton, PA 19341

↵*Corresponding Author: Fran L. DeGrazio. Telephone (610) 594-3190; e-mail: fran.degrazio{at}westpharma.com

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Holistic Considerations in Optimizing a Sterile Product Package to Ensure Container Closure Integrity

Fran L. Degrazio

PDA Journal of Pharmaceutical Science and Technology Jan 2018, 72 (1) 15-34; DOI: 10.5731/pdajpst.2017.007658

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Holistic Considerations in Optimizing a Sterile Product Package to Ensure Container Closure Integrity

Fran L. Degrazio

PDA Journal of Pharmaceutical Science and Technology Jan 2018, 72 (1) 15-34; DOI: 10.5731/pdajpst.2017.007658

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Time Temperature Superposition Evaluation and Modeling for Container Closure System's Seal Performance at Low Temperatures
Balancing Container Closure Integrity and Aesthetics for a Robust Aseptic or Sterile Vial Packaging System
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Keywords

CCI
Container closure integrity
Integral System
Leak rate
Vial system
Leakage sealing optimization
Seal Integrity
Residual seal force

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Parenteral Drug Association, Inc.