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Research ArticleResearch

Time-Dependent Testing Evaluation and Modeling for Rubber Stopper Seal Performance

Qingyu Zeng and Xia Zhao
PDA Journal of Pharmaceutical Science and Technology March 2018, 72 (2) 134-148; DOI: https://doi.org/10.5731/pdajpst.2017.008052
Qingyu Zeng
West Pharmaceutical Services, Inc., Exton, PA
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Xia Zhao
West Pharmaceutical Services, Inc., Exton, PA
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  • Article
  • Figures & Data
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Article Information

vol. 72 no. 2 134-148
DOI 
https://doi.org/10.5731/pdajpst.2017.008052
PubMed 
29158288

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online March 23, 2018.

Article Versions

  • previous version (November 20, 2017 - 18:35).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© PDA, Inc. 2018

Author Information

  1. Qingyu Zeng and
  2. Xia Zhao
  1. West Pharmaceutical Services, Inc., Exton, PA
  1. Corresponding Author: Qingyu Zeng, West Pharmaceutical Services, Inc., 530 Herman O. West Drive, Exton, PA 19341; e-mail: qingyu.zeng{at}westpharma.com
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PDA Journal of Pharmaceutical Science and Technology: 72 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 72, Issue 2
March/April 2018
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Time-Dependent Testing Evaluation and Modeling for Rubber Stopper Seal Performance
Qingyu Zeng, Xia Zhao
PDA Journal of Pharmaceutical Science and Technology Mar 2018, 72 (2) 134-148; DOI: 10.5731/pdajpst.2017.008052

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Time-Dependent Testing Evaluation and Modeling for Rubber Stopper Seal Performance
Qingyu Zeng, Xia Zhao
PDA Journal of Pharmaceutical Science and Technology Mar 2018, 72 (2) 134-148; DOI: 10.5731/pdajpst.2017.008052
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  • Article
    • Abstract
    • Introduction
    • Experimental Testing and Modeling
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Keywords

  • Compression stress relaxation (CSR)
  • Residual seal force (RSF)
  • Container closure system (CCS)
  • Container closure integrity (CCI)
  • Stopper
  • Vial
  • Cap
  • Seal
  • Capping
  • Time-dependent
  • Temperature-dependent
  • Maxwell-Wiechert model
  • Kohlrausch-Williams-Watts (KWW) stretched exponential function

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