Time-Dependent Testing Evaluation and Modeling for Rubber Stopper Seal Performance

Qingyu Zeng; Xia Zhao

doi:10.5731/pdajpst.2017.008052

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Time-Dependent Testing Evaluation and Modeling for Rubber Stopper Seal Performance

Qingyu Zeng and Xia Zhao

PDA Journal of Pharmaceutical Science and Technology March 2018, 72 (2) 134-148; DOI: https://doi.org/10.5731/pdajpst.2017.008052

Qingyu Zeng

West Pharmaceutical Services, Inc., Exton, PA

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Xia Zhao

West Pharmaceutical Services, Inc., Exton, PA

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vol. 72 no. 2 134-148

DOI

https://doi.org/10.5731/pdajpst.2017.008052

PubMed

29158288

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Parenteral Drug Association (PDA)

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1079-7440

Online ISSN

1948-2124

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Published online March 23, 2018.

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previous version (November 20, 2017 - 18:35).
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Qingyu Zeng and
Xia Zhao

West Pharmaceutical Services, Inc., Exton, PA

Corresponding Author: Qingyu Zeng, West Pharmaceutical Services, Inc., 530 Herman O. West Drive, Exton, PA 19341; e-mail: qingyu.zeng{at}westpharma.com

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Time-Dependent Testing Evaluation and Modeling for Rubber Stopper Seal Performance

Qingyu Zeng, Xia Zhao

PDA Journal of Pharmaceutical Science and Technology Mar 2018, 72 (2) 134-148; DOI: 10.5731/pdajpst.2017.008052

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Time-Dependent Testing Evaluation and Modeling for Rubber Stopper Seal Performance

Qingyu Zeng, Xia Zhao

PDA Journal of Pharmaceutical Science and Technology Mar 2018, 72 (2) 134-148; DOI: 10.5731/pdajpst.2017.008052

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Keywords

Compression stress relaxation (CSR)
Residual seal force (RSF)
Container closure system (CCS)
Container closure integrity (CCI)
Stopper
Vial
Cap
Seal
Capping
Time-dependent
Temperature-dependent
Maxwell-Wiechert model
Kohlrausch-Williams-Watts (KWW) stretched exponential function

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