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Research ArticleResearch

Time-Dependent Testing Evaluation and Modeling for Rubber Stopper Seal Performance

Qingyu Zeng and Xia Zhao
PDA Journal of Pharmaceutical Science and Technology March 2018, 72 (2) 134-148; DOI: https://doi.org/10.5731/pdajpst.2017.008052
Qingyu Zeng
West Pharmaceutical Services, Inc., Exton, PA
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Xia Zhao
West Pharmaceutical Services, Inc., Exton, PA
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PDA Journal of Pharmaceutical Science and Technology: 72 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 72, Issue 2
March/April 2018
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Time-Dependent Testing Evaluation and Modeling for Rubber Stopper Seal Performance
Qingyu Zeng, Xia Zhao
PDA Journal of Pharmaceutical Science and Technology Mar 2018, 72 (2) 134-148; DOI: 10.5731/pdajpst.2017.008052

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Time-Dependent Testing Evaluation and Modeling for Rubber Stopper Seal Performance
Qingyu Zeng, Xia Zhao
PDA Journal of Pharmaceutical Science and Technology Mar 2018, 72 (2) 134-148; DOI: 10.5731/pdajpst.2017.008052
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  • Article
    • Abstract
    • Introduction
    • Experimental Testing and Modeling
    • Results and Discussion
    • Conclusion
    • Conflict of Interest Declaration
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    • References
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  • References
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Cited By...

  • A New Integrated Modeling Approach with Case Studies for Gas Transmission of Container Closure Headspace
  • Quantifying the Vial-Capping Process: Reexamination Using Micro-Computed Tomography
  • Long-Term Study of Container Closure Integrity of Rubber-Glass Vial Systems by Multiple Methods
  • Time Temperature Superposition Evaluation and Modeling for Container Closure System's Seal Performance at Low Temperatures
  • Balancing Container Closure Integrity and Aesthetics for a Robust Aseptic or Sterile Vial Packaging System
  • Google Scholar

More in this TOC Section

  • Quantitative and Qualitative Evaluation of Microorganism Profile Identified in Bioburden Analysis in a Biopharmaceutical Facility in Brazil: Criteria for Classification and Management of Results
  • Evaluation of Extreme Depyrogenation Conditions on the Surface Hydrolytic Resistance of Glass Containers for Pharmaceutical Use
  • A Holistic Approach for Filling Volume Variability Evaluation and Control with Statistical Tool
Show more Research

Similar Articles

Keywords

  • Compression stress relaxation (CSR)
  • Residual seal force (RSF)
  • Container closure system (CCS)
  • Container closure integrity (CCI)
  • Stopper
  • Vial
  • Cap
  • Seal
  • Capping
  • Time-dependent
  • Temperature-dependent
  • Maxwell-Wiechert model
  • Kohlrausch-Williams-Watts (KWW) stretched exponential function

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