Evaluation of an ATP-Bioluminescence Rapid Microbial Screening Method for In-Process Biologics

Scott Spaeth; Quynh Tran; Zhiyun Liu

doi:10.5731/pdajpst.2018.008557

Research ArticleTechnology/Application

Evaluation of an ATP-Bioluminescence Rapid Microbial Screening Method for In-Process Biologics

Scott Spaeth, Quynh Tran and Zhiyun Liu

PDA Journal of Pharmaceutical Science and Technology November 2018, 72 (6) 574-583; DOI: https://doi.org/10.5731/pdajpst.2018.008557

Scott Spaeth

Bristol-Myers Squibb, Biologics Lead Discovery, Redwood City, CA, USA

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Quynh Tran

Bristol-Myers Squibb, Biologics Lead Discovery, Redwood City, CA, USA

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Zhiyun Liu

Bristol-Myers Squibb, Biologics Lead Discovery, Redwood City, CA, USA

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For correspondence: Zhiyun.Liu@bms.com

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vol. 72 no. 6 574-583

DOI

https://doi.org/10.5731/pdajpst.2018.008557

PubMed

29954921

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online December 4, 2018.

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previous version (June 27, 2018 - 21:50).
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Scott Spaeth,
Quynh Tran and
Zhiyun Liu*

Bristol-Myers Squibb, Biologics Lead Discovery, Redwood City, CA, USA

↵* Corresponding Author: Bristol-Myers Squibb, 700 Bay Rd., Redwood City, CA 94063; e-mail: Zhiyun.Liu{at}bms.com

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Evaluation of an ATP-Bioluminescence Rapid Microbial Screening Method for In-Process Biologics

Scott Spaeth, Quynh Tran, Zhiyun Liu

PDA Journal of Pharmaceutical Science and Technology Nov 2018, 72 (6) 574-583; DOI: 10.5731/pdajpst.2018.008557

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Evaluation of an ATP-Bioluminescence Rapid Microbial Screening Method for In-Process Biologics

Scott Spaeth, Quynh Tran, Zhiyun Liu

PDA Journal of Pharmaceutical Science and Technology Nov 2018, 72 (6) 574-583; DOI: 10.5731/pdajpst.2018.008557

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Keywords

Biologics microbial monitoring
Adenosine triphosphate-based bioluminescence
direct inoculation of enrichment media
Tryptic soy broth
Tryptone–azolectin–Tween
microbial spiking

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