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Research ArticleResearch

Application of Arrhenius Kinetics to Acceleration of Controlled Extraction Studies

Dennis Jenke
PDA Journal of Pharmaceutical Science and Technology March 2019, 73 (2) 135-169; DOI: https://doi.org/10.5731/pdajpst.2018.009050
Dennis Jenke
Triad Scientific Solutions, LLC, Hawthorn Woods, IL
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  • For correspondence: dennisjenke@triadscientificsolutions.com
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PDA Journal of Pharmaceutical Science and Technology: 73 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 73, Issue 2
March/April 2019
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Application of Arrhenius Kinetics to Acceleration of Controlled Extraction Studies
Dennis Jenke
PDA Journal of Pharmaceutical Science and Technology Mar 2019, 73 (2) 135-169; DOI: 10.5731/pdajpst.2018.009050

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Application of Arrhenius Kinetics to Acceleration of Controlled Extraction Studies
Dennis Jenke
PDA Journal of Pharmaceutical Science and Technology Mar 2019, 73 (2) 135-169; DOI: 10.5731/pdajpst.2018.009050
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  • Article
    • Abstract
    • Introduction
    • Data Analysis
    • Case Study #1: Leaching of Organic Extractables From Irradiated Multilayered Bioprocessing Bags
    • Case Study #2: Leaching of Organic Extractables Into Eye-Drop Solutions
    • Case Study #3: Leaching of Low-Molecular-Weight Organic Extractables from Polyethylene Terephthalate Bottles
    • Case Study #4: Leaching of 2-(Diethylhexyl) Phthalate into Drug Products from Infusion Bags
    • Case Study #5: Leaching of 2-(Diethylhexyl) Phthalate into Ethanol/Water Mixtures
    • Case Study #6: Leaching of Styrene Monomer From Polystyrene Disks into 75% (v/v) Ethanol/Water
    • Case Study #7: Leaching of a Photoinitiator Used in Printing Inks into 95% (v/v) Ethanol/Water
    • Case Study #8: Leaching of Dibutyl Phthalate from Bromobutyl Rubber
    • Case Study #9: Leaching of Acrylic Monomers from Methacrylate Polymers and Effect of Solvent-Induced Swelling
    • Case Study #10: Uptake of Dipropyl Phthalate by a Multilayered Polyolefin Bag
    • Discussion and Conclusions
    • Conflict of Interest Declaration
    • References
  • Figures & Data
  • Info & Metrics
  • References
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More in this TOC Section

  • Container Closure Integrity of Vial Primary Packaging Systems under Frozen Storage Conditions: A Case Study
  • Advances in Large Volume Subcutaneous Injections: A Pilot Tolerability Study of an Innovative Needle-Free Injection Platform
  • Quantification and Stability Impact Assessment of Drop Stresses in Biologic Drug Products
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Keywords

  • Arrhenius kinetics
  • Extractables
  • controlled extraction study
  • acceleration
  • Pharmaceutical packaging

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